Microinjections of muscimol, a GABA receptor agonist, into the periaqueductal gray matter (PAG) counter-acted the antinociceptive effect of morphine in rats, as measured by the "tail-flick" method. Muscimol's effect was partially reversed by bicuculline.
Periaqueductal gray matter involvement in the muscimol-induced decrease of morphine antinociception / F. Zambotti, N. Zonta, M. Parenti, R. Tommasi, L. Vicentini, F. Conci, P. Mantegazza. - In: NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY. - ISSN 0028-1298. - 318:4(1982 Mar), pp. 368-369.
Periaqueductal gray matter involvement in the muscimol-induced decrease of morphine antinociception
L. Vicentini;
1982
Abstract
Microinjections of muscimol, a GABA receptor agonist, into the periaqueductal gray matter (PAG) counter-acted the antinociceptive effect of morphine in rats, as measured by the "tail-flick" method. Muscimol's effect was partially reversed by bicuculline.
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