A recent physical analysis of the disintegration phenomenon expresses the disintegration force in terms of an exponential expression containing an expansion rate constant, k, and an exponent, n, which varies depending on the composition of the tablets tested. It is shown that the expansion rate constant, k, is strongly dependent on experimentation temperature and that it can be analyzed using an Arrhenius-type expression. Thus, an activation energy can be calculated. Experimental results of disintegration of tablets prepared from calcium diphosphate dihydrate and containing various swellable disintegrants are presented and analyzed.
Energetics of tablet disintegration / N. PEPPAS, P. COLOMBO, U. CONTE, A. GAZZANIGA, C. CARAMELLA, F. FERRARI. - In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. - ISSN 0378-5173. - 51:1(1989), pp. 77-83. [10.1016/0378-5173(89)90078-1]
Energetics of tablet disintegration
A. Gazzaniga;
1989
Abstract
A recent physical analysis of the disintegration phenomenon expresses the disintegration force in terms of an exponential expression containing an expansion rate constant, k, and an exponent, n, which varies depending on the composition of the tablets tested. It is shown that the expansion rate constant, k, is strongly dependent on experimentation temperature and that it can be analyzed using an Arrhenius-type expression. Thus, an activation energy can be calculated. Experimental results of disintegration of tablets prepared from calcium diphosphate dihydrate and containing various swellable disintegrants are presented and analyzed.
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