To assess the risk of mother-to-infant transmission of hepatitis C virus (HCV), we followed up 116 babies of anti-HCV positive mothers, of whom 22 were coinfected with HIV and 94 had HCV alone. None of the babies whose mothers had HCV alone acquired HCV, while 8 babies (36%; p<0·001) of mothers co-infected with HIV acquired HCV (5 babies) or HCV and HIV (3). There was no association between any specific maternal HCV genotype and enhanced risk of neonatal infection. HCV-RNA levels were significantly higher (p<0·05) in mothers with HIV coinfection than in those with HCV alone. These data indicate that maternal HIV status correlates with enhanced level of viraemia which favours neonatal infection.
Mother-to-infant transmission of hepatitis C virus / A.R. Zanetti, E. Tanzi, S. Paccagnini, N. Principi, G. Pizzocolo, M.L. Caccamo, E. D'Amico, G. Cambié', L. Vecchi. - In: THE LANCET. - ISSN 0140-6736. - 345:8945(1995), pp. 289-291.
|Titolo:||Mother-to-infant transmission of hepatitis C virus|
ZANETTI, ALESSANDRO REMO (Primo)
TANZI, ELISABETTA (Secondo)
|Settore Scientifico Disciplinare:||Settore MED/42 - Igiene Generale e Applicata|
|Data di pubblicazione:||1995|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/S0140-6736(95)90277-5|
|Appare nelle tipologie:||01 - Articolo su periodico|