The Saccharomyces cerevisiae strain XL16-5B exhibited a fungicidal response to treatment with ketoconazole. Cell death became apparent during prolonged treatment over 72 h following an initial period over 24 h where viable cells were found and limited cell division occurred. Sterol analysis showed some differences between XL16-5B and the strain XY729-5a, which had a fungistatic response to ketoconazole. In particular, the level of ergosterol was higher in XL16-5B and remained high during treatment.
Studies on azole-induced cell death inSaccharomyces cerevisiae / S. L. Kelly, S. Kenna, A. Arnoldi, D. E. Kelly. - In: FEMS MICROBIOLOGY LETTERS. - ISSN 0378-1097. - 115:2-3(1994), pp. 219-222.
Studies on azole-induced cell death inSaccharomyces cerevisiae
A. ArnoldiPenultimo
;
1994
Abstract
The Saccharomyces cerevisiae strain XL16-5B exhibited a fungicidal response to treatment with ketoconazole. Cell death became apparent during prolonged treatment over 72 h following an initial period over 24 h where viable cells were found and limited cell division occurred. Sterol analysis showed some differences between XL16-5B and the strain XY729-5a, which had a fungistatic response to ketoconazole. In particular, the level of ergosterol was higher in XL16-5B and remained high during treatment.
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