TREX1 (three prime repair exonuclease 1) degrades excess HIV-1 DNA thereby preventing recognition by innate immunity receptors and type I interferon responses. Analyses performed in two HIV-exposed seronegative (HESN) cohorts did not show any differences in TREX1 sequence, SNPs frequency, or expression in HESN compared to controls, suggesting that - despite its central role in the HIV-1 infection process- genetic diversity at TREX1 is not a major determinant of susceptibility to infection in humans.
Genetic variability at the TREX1 locus is not associated with natural resistance to HIV-1 infection / M. Sironi, M. Biasin, D. Forni, R. Cagliani, M. de Luca, I. Saulle, S.L. Caputo, F. Mazzotta, J. Macias, J.A. Pineda, A. Caruz, M. Clerici. - In: AIDS. - ISSN 0269-9370. - 26:11(2012 Jul 17), pp. 1443-1445. [10.1097/QAD.0b013e328354b3c2]
Genetic variability at the TREX1 locus is not associated with natural resistance to HIV-1 infection
M. BiasinSecondo
;M. de Luca;I. Saulle;M. ClericiUltimo
2012
Abstract
TREX1 (three prime repair exonuclease 1) degrades excess HIV-1 DNA thereby preventing recognition by innate immunity receptors and type I interferon responses. Analyses performed in two HIV-exposed seronegative (HESN) cohorts did not show any differences in TREX1 sequence, SNPs frequency, or expression in HESN compared to controls, suggesting that - despite its central role in the HIV-1 infection process- genetic diversity at TREX1 is not a major determinant of susceptibility to infection in humans.
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