The possibility of using high viscosity grades of hydroxypropylmethylcellulose (HPMC) as a film forming agent in a conventional coating process has been investigated. Ethanol/water mixtures having different weight ratios (5 to 18) and containing up to 5 % of HPMC revealed to be suitable. The influence of some formulation additives (talc, PVP and plasticizers) on both the overall coating process and the in-vitro release profiles of ketoprofen containing coated tablets was also investigated and discussed.
High-Viscosity HPMC as a Film-Coating Agent / G. Maffione, P. Iamartino, G. Guglielmini, A. Gazzaniga. - In: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY. - ISSN 0363-9045. - 19:16(1993), pp. 2043-2053.
High-Viscosity HPMC as a Film-Coating Agent
A. GazzanigaUltimo
1993
Abstract
The possibility of using high viscosity grades of hydroxypropylmethylcellulose (HPMC) as a film forming agent in a conventional coating process has been investigated. Ethanol/water mixtures having different weight ratios (5 to 18) and containing up to 5 % of HPMC revealed to be suitable. The influence of some formulation additives (talc, PVP and plasticizers) on both the overall coating process and the in-vitro release profiles of ketoprofen containing coated tablets was also investigated and discussed.
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