Patients undergoing long-term highly active antiretroviral therapy treatment are probably at a higher risk of various HIV-related complications. Hyperactivation of The mammalian target of rapamycin (mTOR) has been found to contribute to dysregulated apoptosis and autophagy which determine CD4(+)-T-cell loss, impaired function of innate immunity and development of neurocognitive disorders. Dysregulated mTOR activation has also been shown to play a key part in the development of nephropathy and in the pathogenesis of HIV-associated malignancies. These studies strongly support a multifunctional key role for mTOR in the pathogenesis of HIV-related disorders and suggest that specific mTOR inhibitors could represent a novel approach for the prevention and treatment of these pathologies

mTOR as a multifunctional therapeutic target in HIV infection / F. Nicoletti, P. Fagone, P. Meroni, J. McCubrey, K. Bendtzen. - In: DRUG DISCOVERY TODAY. - ISSN 1359-6446. - 16:15-16(2011 Aug), pp. 715-721. [10.1016/j.drudis.2011.05.008]

mTOR as a multifunctional therapeutic target in HIV infection

P. Meroni;
2011

Abstract

Patients undergoing long-term highly active antiretroviral therapy treatment are probably at a higher risk of various HIV-related complications. Hyperactivation of The mammalian target of rapamycin (mTOR) has been found to contribute to dysregulated apoptosis and autophagy which determine CD4(+)-T-cell loss, impaired function of innate immunity and development of neurocognitive disorders. Dysregulated mTOR activation has also been shown to play a key part in the development of nephropathy and in the pathogenesis of HIV-associated malignancies. These studies strongly support a multifunctional key role for mTOR in the pathogenesis of HIV-related disorders and suggest that specific mTOR inhibitors could represent a novel approach for the prevention and treatment of these pathologies
Settore MED/16 - Reumatologia
ago-2011
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/171743
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