The synthesis, crystal structures, physicochemical properties and complex formation constants of [Cu(phen)2(L)] (ClO4)2 complexes, where phen is 1,10-ortho-phenanthroline and L is a series of substituted imidazolidine-2- thione, have been studied. Single crystal X-ray diffraction revealed a distorted trigonal–bipyramidal geometry for all the molecules. The complex formation constants were determined in nonaqueous media by spectrophotometricmeasurements. Testing copper(II) complexes inmouse neuroblastomaN2a cells persistently infected with the 22L strain of the scrapie prion protein (22L-N2a) resulted in high cytotoxicity but no antiprion activity at nontoxic doses.

Synthesis, structural characterization, formation constants and in vitro cytotoxicity of phenanthroline and imidazolidine-2-thione copper(II) complexes / T. Pivetta, M.D. Cannas, F. Demartin, C. Castellano, S. Vascellari, G. Verani, F. Isaia. - In: JOURNAL OF INORGANIC BIOCHEMISTRY. - ISSN 0162-0134. - 105:3(2011), pp. 329-338. [10.1016/j.jinorgbio.2010.11.017]

Synthesis, structural characterization, formation constants and in vitro cytotoxicity of phenanthroline and imidazolidine-2-thione copper(II) complexes

F. Demartin;C. Castellano;
2011

Abstract

The synthesis, crystal structures, physicochemical properties and complex formation constants of [Cu(phen)2(L)] (ClO4)2 complexes, where phen is 1,10-ortho-phenanthroline and L is a series of substituted imidazolidine-2- thione, have been studied. Single crystal X-ray diffraction revealed a distorted trigonal–bipyramidal geometry for all the molecules. The complex formation constants were determined in nonaqueous media by spectrophotometricmeasurements. Testing copper(II) complexes inmouse neuroblastomaN2a cells persistently infected with the 22L strain of the scrapie prion protein (22L-N2a) resulted in high cytotoxicity but no antiprion activity at nontoxic doses.
Copper(II) complexes; X-ray structure; complex formation constants; cytotoxicity
Settore CHIM/03 - Chimica Generale e Inorganica
2011
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/160007
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