Chemokines are important components of cancer-related inflammation. In this issue of Cancer Cell, Chen et al. report that the chemokine CCL18, produced by tumor-associated macrophages, promotes malignant behavior and correlates with metastasis in human breast cancer. Unexpectedly, PITPNM3/Nir1, a molecule unrelated to chemokine receptors, was identified as its elusive receptor.
Chemokines and cancer: a fatal attraction / R. Bonecchi, M. Locati, A. Mantovani. - In: CANCER CELL. - ISSN 1535-6108. - 19:4(2011 Apr 12), pp. 434-435. [10.1016/j.ccr.2011.03.017]
Chemokines and cancer: a fatal attraction
R. BonecchiPrimo
;M. LocatiSecondo
;A. MantovaniUltimo
2011
Abstract
Chemokines are important components of cancer-related inflammation. In this issue of Cancer Cell, Chen et al. report that the chemokine CCL18, produced by tumor-associated macrophages, promotes malignant behavior and correlates with metastasis in human breast cancer. Unexpectedly, PITPNM3/Nir1, a molecule unrelated to chemokine receptors, was identified as its elusive receptor.
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