Eight known and two new triterpenoid derivatives, neemfruitins A (9) and B (10), have been isolated from the fruits of neem, Azadirachta indica, a traditional antimalarial plant used by Asian and African populations. In vitro antiplasmodial tests evidenced a significant activity of the known gedunin and azadirone and the new neemfruitin A and provided useful information about the structure-antimalarial activity relationships in the limonoid class.
Antiiplasmodial triterpenoids from the fruits of neem, Azadirachta indica / G. Chianese, S.R. Yerbanga, L. Lucantoni, A. Habluetzel, N. Basilico, D. Taramelli, E. Fattorusso, O. Taglialatela-Scafati. - In: JOURNAL OF NATURAL PRODUCTS. - ISSN 0163-3864. - 73:8(2010 Aug 27), pp. 1448-1452. [10.1021/np100325q]
Antiiplasmodial triterpenoids from the fruits of neem, Azadirachta indica
N. Basilico;D. Taramelli;
2010
Abstract
Eight known and two new triterpenoid derivatives, neemfruitins A (9) and B (10), have been isolated from the fruits of neem, Azadirachta indica, a traditional antimalarial plant used by Asian and African populations. In vitro antiplasmodial tests evidenced a significant activity of the known gedunin and azadirone and the new neemfruitin A and provided useful information about the structure-antimalarial activity relationships in the limonoid class.
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