The production of no-carrier-added (NCA) alpha emitter 211At/211gPo radionuclides for high-LET targeted radiotherapy and immunoradiotherapy, through the 209Bi(alpha,2n) reaction, together with the required wet radiochemistry and radioanalytical quality controls carried out at LASA is described, through dedicated irradiation experiments at the MC-40 cyclotron of JRC-Ispra. The amount of both the gamma-emitter 210At and its long half-lived alpha-emitting daughter 210Po is optimised and minimised by appropriate choice of energy and energy loss of alpha particle beam. The measured excitation functions for production of the main radioisotopic impurity 210At- 210Po are compared with theoretical predictions from model calculations performed at ENEA.

Optimisation study of a-cyclotron production of At-211/Po-211g for high-LET metabolic radiotherapy purposes / F. Groppi, M.L. Bonardi, C. Birattari, E. Menapace, K. Abbas, U. Holzwarth, A. Alfarano, S. Morzenti, C. Zona, Z.B. Alfassi. - In: APPLIED RADIATION AND ISOTOPES. - ISSN 0969-8043. - 63:5-6(2005 Nov), pp. 621-631.

Optimisation study of a-cyclotron production of At-211/Po-211g for high-LET metabolic radiotherapy purposes

F. Groppi
Primo
;
M.L. Bonardi
Secondo
;
C. Birattari;S. Morzenti;
2005

Abstract

The production of no-carrier-added (NCA) alpha emitter 211At/211gPo radionuclides for high-LET targeted radiotherapy and immunoradiotherapy, through the 209Bi(alpha,2n) reaction, together with the required wet radiochemistry and radioanalytical quality controls carried out at LASA is described, through dedicated irradiation experiments at the MC-40 cyclotron of JRC-Ispra. The amount of both the gamma-emitter 210At and its long half-lived alpha-emitting daughter 210Po is optimised and minimised by appropriate choice of energy and energy loss of alpha particle beam. The measured excitation functions for production of the main radioisotopic impurity 210At- 210Po are compared with theoretical predictions from model calculations performed at ENEA.
Produzione di No Carrier Added 211At/211gPo, 210At/210Po, reazioni 209Bi(alfa,xn); radioterapia metabolica ad alto LET; funzioni d'eccitazione; bismuto-209; ciclotrone
Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
Settore CHIM/03 - Chimica Generale e Inorganica
nov-2005
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/15761
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