Hodgkin lymphoma relapsing after autologous transplantation (autoSCT) has a dismal outcome. Allogeneic transplantation (alloSCT) using reduced intensity conditioning (RIC) is a salvage option, but its effectiveness is still unclear. To evaluate the role of RIC alloSCT, we designed a retrospective study based on the commitment of attending physicians to perform a salvage alloSCT; thus, only Hodgkin lymphoma patients having human leukocyte antigen-typing immediately after the failed autoSCT were included. Of 185 patients, 122 found an identical sibling (55%), a matched unrelated (32%) or a haploidentical sibling (13%) donor; 63 patients did not find any donor. Clinical features of both groups did not differ. Two-year progression-free (PFS) and overall survival (OS) were better in the donor group (39.3% vs 14.2%, and 66% vs 42%, respectively, P < .001) with a median follow-up of 48 months. In multivariable analysis, having a donor was significant for better PFS and OS (P < .001). Patients allografted in complete remission showed a better PFS and OS. This is the largest study comparing RIC alloSCT versus conventional treatment after a failed auto-SCT, indicating a survival benefit for patients having a donor.
Allogeneic transplantation improves the overall and progression-free survival of Hodgkin lymphoma patients relapsing after autologous transplantation : a retrospective study based on the time of HLA typing and donor availability / B. Sarina, L. Castagna, L. Farina, F. Patriarca, F. Benedetti, A.M. Carella, M. Falda, S.Guidi, F. Ciceri, A. Bonini, S. Ferrari, M. Malagola, E. Morello, G. Milone, B. Bruno, N. Mordini, S. Viviani, A. Levis, L. Giordano, A. Santoro, P. Corradini, Gruppo Italiano Trapianto di Midollo Osseo.. - In: BLOOD. - ISSN 0006-4971. - 115:18(2010 May), pp. 3671-3677.
|Titolo:||Allogeneic transplantation improves the overall and progression-free survival of Hodgkin lymphoma patients relapsing after autologous transplantation : a retrospective study based on the time of HLA typing and donor availability|
CORRADINI, PAOLO (Ultimo)
|Settore Scientifico Disciplinare:||Settore MED/15 - Malattie del Sangue|
|Data di pubblicazione:||mag-2010|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1182/blood-2009-12-253856|
|Appare nelle tipologie:||01 - Articolo su periodico|