A variety of substituted dihydroisobenzofurans can be easily synthesized in high yields by a one-pot three-component approach starting from o-bromoarylaldehydes, methanol, and terminal alkynes. The reaction occurs through an unprecedented cooperative palladium/base promoted coupling/addition/cyclization sequence.
From domino to multicomponent : synthesis of dihydroisobenzofurans / M. Dell'Acqua, D. Facoetti, G. Abbiati, E. Rossi. - In: TETRAHEDRON. - ISSN 0040-4020. - 67:8(2011 Feb 25), pp. 1552-1556. [10.1016/j.tet.2010.12.056]
From domino to multicomponent : synthesis of dihydroisobenzofurans
M. Dell'AcquaPrimo
;D. FacoettiSecondo
;G. Abbiati
;E. RossiUltimo
2011
Abstract
A variety of substituted dihydroisobenzofurans can be easily synthesized in high yields by a one-pot three-component approach starting from o-bromoarylaldehydes, methanol, and terminal alkynes. The reaction occurs through an unprecedented cooperative palladium/base promoted coupling/addition/cyclization sequence.
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