Compounds or formula (I) are described, in which R and R1 groups are as defined here below and include the condensation of the camptothecin molecule in position 20 with a cyclopeptide containing the RGD sequence. Said compounds are endowed both with high affinity for integrin receptors alphavbeta3 and alphavbeta5 and with selective cytotoxic activity on human tumor cell lines at micromolar concentrations
CAMPTOTHECIN DERIVATIVES CONJUGATED IN POSITION 20 WITH INTEGRIN ANTAGONISTS / A. Dal Pozzo, S. Penco, L. Merlini, G. Giannini, M. Tinti, C. Pisano, F. Zunino, D. Alloatti, L. Vesci, S. Dallavalle, M. Ni.
CAMPTOTHECIN DERIVATIVES CONJUGATED IN POSITION 20 WITH INTEGRIN ANTAGONISTS
L. Merlini;S. DallavallePenultimo
;
2005
Abstract
Compounds or formula (I) are described, in which R and R1 groups are as defined here below and include the condensation of the camptothecin molecule in position 20 with a cyclopeptide containing the RGD sequence. Said compounds are endowed both with high affinity for integrin receptors alphavbeta3 and alphavbeta5 and with selective cytotoxic activity on human tumor cell lines at micromolar concentrationsFile in questo prodotto:
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