Compounds or formula (I) are described, in which R and R1 groups are as defined here below and include the condensation of the camptothecin molecule in position 20 with a cyclopeptide containing the RGD sequence. Said compounds are endowed both with high affinity for integrin receptors alphavbeta3 and alphavbeta5 and with selective cytotoxic activity on human tumor cell lines at micromolar concentrations

CAMPTOTHECIN DERIVATIVES CONJUGATED IN POSITION 20 WITH INTEGRIN ANTAGONISTS / A. Dal Pozzo, S. Penco, L. Merlini, G. Giannini, M. Tinti, C. Pisano, F. Zunino, D. Alloatti, L. Vesci, S. Dallavalle, M. Ni.

CAMPTOTHECIN DERIVATIVES CONJUGATED IN POSITION 20 WITH INTEGRIN ANTAGONISTS

L. Merlini;S. Dallavalle
Penultimo
;
2005

Abstract

Compounds or formula (I) are described, in which R and R1 groups are as defined here below and include the condensation of the camptothecin molecule in position 20 with a cyclopeptide containing the RGD sequence. Said compounds are endowed both with high affinity for integrin receptors alphavbeta3 and alphavbeta5 and with selective cytotoxic activity on human tumor cell lines at micromolar concentrations
SIGMA-TAU
Istituto nazionale dei tumori
WO2005/110487
PCT/IT2005/000261
24-nov-2005
Settore CHIM/06 - Chimica Organica
CAMPTOTHECIN DERIVATIVES CONJUGATED IN POSITION 20 WITH INTEGRIN ANTAGONISTS / A. Dal Pozzo, S. Penco, L. Merlini, G. Giannini, M. Tinti, C. Pisano, F. Zunino, D. Alloatti, L. Vesci, S. Dallavalle, M. Ni.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/153738
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