The purpose of this study was to perform a careful neurophysiological examination to identify subclinical signs of botulinum toxin spread distant to the injection site following intragastric injection for obesity treatment. Single-fiber electromyography of extensor digitorum communis and repetitive stimulation of abductor digiti minimi were performed before and 8 days after multiple intragastric injections of botulinum toxin A (Botox, 200 U per patient) or placebo. The study was performed in a randomized double-blind fashion. No patient in either group displayed results indicative of neuromuscular dysfunction either before or after the treatment. No significant change in muscle jitter was observed when comparing baseline with the after-treatment evaluation in either group, and no significant differences between groups were observed. After intragastric botulinum toxin injection no subclinical sign of distant spread was observed. Muscle Nerve, 2010
Botulinum neurotoxin - A does not spread to distant muscles after intragastric injection : a double-blind single-fiber electromyography study / M. Osio, E. Mailland, F. Muscia, C. Nascimbene, A. Vanotti, C. Bana, F.R.M. Corsi, D. Foschi, C. Mariani. - In: MUSCLE & NERVE. - ISSN 0148-639X. - 42:2(2010 Aug), pp. 165-169. [10.1002/mus.21662]
Botulinum neurotoxin - A does not spread to distant muscles after intragastric injection : a double-blind single-fiber electromyography study
A. Vanotti;C. Bana;F.R.M. Corsi;D. FoschiPenultimo
;C. MarianiUltimo
2010
Abstract
The purpose of this study was to perform a careful neurophysiological examination to identify subclinical signs of botulinum toxin spread distant to the injection site following intragastric injection for obesity treatment. Single-fiber electromyography of extensor digitorum communis and repetitive stimulation of abductor digiti minimi were performed before and 8 days after multiple intragastric injections of botulinum toxin A (Botox, 200 U per patient) or placebo. The study was performed in a randomized double-blind fashion. No patient in either group displayed results indicative of neuromuscular dysfunction either before or after the treatment. No significant change in muscle jitter was observed when comparing baseline with the after-treatment evaluation in either group, and no significant differences between groups were observed. After intragastric botulinum toxin injection no subclinical sign of distant spread was observed. Muscle Nerve, 2010Pubblicazioni consigliate
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