The authors treated 10 patients with multifocal motor neuropathy (MMN) responding to an initial course of IV immunoglobulin (IVIg) with periodic infusion for 5 to 12 years (mean 8.2 years). At last follow-up, only two patients had maintained the maximal improvement achieved during therapy while eight worsened despite increasing Ig dosage. This decline started after 3 to 7 years (mean 4.8 years) of therapy and correlated with a reduction of distal compound muscle action potential amplitudes (p < 0.019). The effectiveness of IVIg in MMN often declines after several years possibly associated with the development of axonal degeneration.
How-long is IVIg effective in multifocal motor neuropathy? / F. Terenghi, A. Cappellari, A. Bersano, M. Carpo, S. Barbieri, E. Nobile-Orazio. - In: NEUROLOGY. - ISSN 0028-3878. - 62:4(2004), pp. 666-668.
How-long is IVIg effective in multifocal motor neuropathy?
A. Bersano;M. Carpo;E. Nobile-Orazio
2004
Abstract
The authors treated 10 patients with multifocal motor neuropathy (MMN) responding to an initial course of IV immunoglobulin (IVIg) with periodic infusion for 5 to 12 years (mean 8.2 years). At last follow-up, only two patients had maintained the maximal improvement achieved during therapy while eight worsened despite increasing Ig dosage. This decline started after 3 to 7 years (mean 4.8 years) of therapy and correlated with a reduction of distal compound muscle action potential amplitudes (p < 0.019). The effectiveness of IVIg in MMN often declines after several years possibly associated with the development of axonal degeneration.Pubblicazioni consigliate
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