A series of adenosine analogues differently substituted in N-6-position were synthesized to continue our studies on the relationships between structure and biological activity of iPA. The structures of the compounds were confirmed by standard studies of H-1 NMR, MS and elemental analysis. These molecules were then evaluated for their anti-proliferative activity on bladder cancer cells. We found that some of these compounds possess anti-proliferative activity but have no effect on cell invasion and metalloprotease activity.
N-6-Alkyladenosines: synthesis and evaluation of in vitro anticancer activity / R. Ottria, S. Casati, E. Baldoli, J.A.M. Maier, P. Ciuffreda. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - 18:23(2010), pp. 8396-8402. [10.1016/j.bmc.2010.09.030]
N-6-Alkyladenosines: synthesis and evaluation of in vitro anticancer activity
R. OttriaPrimo
;S. CasatiSecondo
;E. Baldoli;J.A.M. MaierPenultimo
;P. CiuffredaUltimo
2010
Abstract
A series of adenosine analogues differently substituted in N-6-position were synthesized to continue our studies on the relationships between structure and biological activity of iPA. The structures of the compounds were confirmed by standard studies of H-1 NMR, MS and elemental analysis. These molecules were then evaluated for their anti-proliferative activity on bladder cancer cells. We found that some of these compounds possess anti-proliferative activity but have no effect on cell invasion and metalloprotease activity.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
