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IRIS è il sistema di gestione integrata dei dati della ricerca (persone, progetti, pubblicazioni, attività) adottato dall'Università degli Studi di Milano.
AIR nasce in UNIMI nel 2006 con lo scopo di raccogliere, documentare e conservare le informazioni sulla produzione scientifica dell'Università degli Studi di Milano e costituisce di fatto l'Anagrafe della ricerca dell'Ateneo.
EnglishThe work aimed to study a new mucoadhesive prolonged release tablet containing 24 μg clobetasol-17 propionate (CP) suitable for the management of oral lichen planus. Low swellable dosage forms were designed by combining a mucoadhesive polymer , i.e. poly(sodium methacrylate, methylmethacrylate), with hydroxypropylmethylcellulose and MgCl2. This formulation was selected to modify the tablet erosion rate in order to obtain a release of CP over a 6 h period. A double-blind controlled study was performed using three groups of patient (n=16) which received 3 applications-a-day over 4 weeks of the developed CP tablets (group CP-T), placebo tablets (group CP-P) or commercial CP ointment for cutaneous application (123 μg/application) extemporary mixed with OrabaseTM (group CP-O). At the end of the study, pain and ulceration resolved in 13/16 and 11/16 patients of group CP-T and group CP-O, respectively. In the group CP-O, a transient acute hyperaemic candidosis (n=2) and taste alteration (n=4) were also observed. No changes in clinical signs of partients in the group CP-P were evident. The application of mucoadhesive tablet containing 24 μg CP 3 times-a-day appeared to be effective, avoiding the side-effects of the generally used treatment.
A new mucoadhesive dosage form for the management of oral lichen planus: formulation study and clinical study / F. Cilurzo , C.G.M. Gennari , F. Selmin, J.B. Epstein, G.M. Gaeta, G. Colella, P. Minghetti. - In: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. - ISSN 0939-6411. - 76:3(2010 Nov), pp. 437-442.
| Titolo: | A new mucoadhesive dosage form for the management of oral lichen planus: formulation study and clinical study |
| Autori: | CILURZO, FRANCESCO (Primo) GENNARI, CHIARA GRAZIA MILENA (Secondo) MINGHETTI, PAOLA (Ultimo) |
| Parole Chiave: | Mucoadhesive tablet; Oral lichen planus; Topical corticosteroids |
| Settore Scientifico Disciplinare: | Settore CHIM/09 - Farmaceutico Tecnologico Applicativo |
| Data di pubblicazione: | nov-2010 |
| Rivista: | |
| Tipologia: | Article (author) |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.ejpb.2010.07.014 |
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