In an effort to decrease the toxicity and improve the stability of the E-ring of camptothecin, new analogues with an 'inverted' lactone ring were designed and synthesized. The compounds retained a good cytotoxic activity on human non-small lung cancer cells H-460.
Synthesis of new cytotoxic E-ring modified camptothecins / S. Cananzi, S. Dallavalle, A. Bargiotti, L. Merlini, R. Artali. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 51:10(2010 Dec 15), pp. 6489-6492. [10.1016/j.tetlet.2010.09.130]
Synthesis of new cytotoxic E-ring modified camptothecins
S. CananziPrimo
;S. DallavalleSecondo
;L. MerliniPenultimo
;R. ArtaliUltimo
2010
Abstract
In an effort to decrease the toxicity and improve the stability of the E-ring of camptothecin, new analogues with an 'inverted' lactone ring were designed and synthesized. The compounds retained a good cytotoxic activity on human non-small lung cancer cells H-460.File in questo prodotto:
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