In an effort to decrease the toxicity and improve the stability of the E-ring of camptothecin, new analogues with an 'inverted' lactone ring were designed and synthesized. The compounds retained a good cytotoxic activity on human non-small lung cancer cells H-460.

Synthesis of new cytotoxic E-ring modified camptothecins / S. Cananzi, S. Dallavalle, A. Bargiotti, L. Merlini, R. Artali. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 51:10(2010 Dec 15), pp. 6489-6492. [10.1016/j.tetlet.2010.09.130]

Synthesis of new cytotoxic E-ring modified camptothecins

S. Cananzi
Primo
;
S. Dallavalle
Secondo
;
L. Merlini
Penultimo
;
R. Artali
Ultimo
2010

Abstract

In an effort to decrease the toxicity and improve the stability of the E-ring of camptothecin, new analogues with an 'inverted' lactone ring were designed and synthesized. The compounds retained a good cytotoxic activity on human non-small lung cancer cells H-460.
Camptothecin ; Synthesis ; Antitumour activity ; Topoisomerase I ; Molecular docking
Settore CHIM/06 - Chimica Organica
15-dic-2010
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/148993
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