Plasticity is a hallmark of cells of the myelomonocytic lineage. In response to innate recognition or signals from lymphocyte subsets, mononuclear phagocytes undergo adaptive responses. Shaping of monocyte-macrophage function is an essential component of resistance to pathogens, tissue damage and repair. The orchestration of myelomonocytic cell function is a key element that links inflammation and cancer and provides a paradigm for macrophage plasticity and function. A better understanding of the molecular basis of myelomonocytic cell plasticity will open new vistas in immunopathology and therapeutic intervention.
Macrophage plasticity and interaction with lymphocyte subsets : cancer as a paradigm / S.K. Biswas, A. Mantovani. - In: NATURE IMMUNOLOGY. - ISSN 1529-2908. - 11:10(2010 Oct), pp. 889-896. [10.1038/ni.1937]
Macrophage plasticity and interaction with lymphocyte subsets : cancer as a paradigm
A. MantovaniUltimo
2010
Abstract
Plasticity is a hallmark of cells of the myelomonocytic lineage. In response to innate recognition or signals from lymphocyte subsets, mononuclear phagocytes undergo adaptive responses. Shaping of monocyte-macrophage function is an essential component of resistance to pathogens, tissue damage and repair. The orchestration of myelomonocytic cell function is a key element that links inflammation and cancer and provides a paradigm for macrophage plasticity and function. A better understanding of the molecular basis of myelomonocytic cell plasticity will open new vistas in immunopathology and therapeutic intervention.Pubblicazioni consigliate
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