In this study we analyzed the effect on behavior of a chronic exposure to brain-derived neurotrophic factor (BDNF), by analysing a mouse line overexpressing BDNF under the αCaMKII promoter, which drives the transgene expression exclusively to principal neurons of the forebrain. BDNF transgenic mice and their WT littermates were examined with a battery of behavioral tests, in order to evaluate motor coordination, learning, short and long-term memory formation. Our results demonstrate that chronic BDNF overexpression in the central nervous system (CNS) causes learning deficits and short-term memory impairments, both in spatial and instrumental learning tasks. This observation suggests that a widespread increase in BDNF in forebrain networks may result in adverse effects on learning and memory formation.
Brain-derived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairments / C. Cunha, A. Angelucci, A. D'Antoni, M.D. Dobrossy, S.B. Dunnett, N. Berardi, R. Brambilla. - In: NEUROBIOLOGY OF DISEASE. - ISSN 0969-9961. - 33:3(2009 Mar), pp. 358-368.
Brain-derived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairments
A. D'Antoni;
2009
Abstract
In this study we analyzed the effect on behavior of a chronic exposure to brain-derived neurotrophic factor (BDNF), by analysing a mouse line overexpressing BDNF under the αCaMKII promoter, which drives the transgene expression exclusively to principal neurons of the forebrain. BDNF transgenic mice and their WT littermates were examined with a battery of behavioral tests, in order to evaluate motor coordination, learning, short and long-term memory formation. Our results demonstrate that chronic BDNF overexpression in the central nervous system (CNS) causes learning deficits and short-term memory impairments, both in spatial and instrumental learning tasks. This observation suggests that a widespread increase in BDNF in forebrain networks may result in adverse effects on learning and memory formation.Pubblicazioni consigliate
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