Background and Objectives: In recent years, a potential relationship between, migraine, stroke and patent foramen ovale (PFO) has emerged. We aimed to investigate the role of transcatheter closure of interatrial septal abnormalities on the occurrence of migraine. Methods: BioMedCentral, Google Scholar and PubMed from January 2000 to December 2008 were systematically searched for pertinent clinical studies. Secondary sources were also used. Secondary prevention studies of transcatheter closure for patent foramen ovale were required to include at least more than 10 patients followed for more than 6 months. The primary end-point was the rate of cured or significantly improved migraine after percutaneous PFO closure. Results: After excluding 634 citations, we finally included a total of 14 studies for a total of 1,434 patients. Forty-two percent of the subjects included suffered from migraine, while most had a previous history of transient ischemic attack/stroke and were investigated retrospectively. Quantitative synthesis showed that complete cure of migraine 47.7% (95% CI 30–66%), while resolution or significant improvement of migraine occurred in 76 % (95% C.I. 65.6–86.5 %) of cases. Conclusions: Notwithstanding the limitations inherent in the primary studies, this systematic review suggests that a significant group of subjects with migraine, in particular if treated after a neurological event, may benefit from percutaneous closure of their interatrial septal defect. However, many questions remain un-solved.

Systematic review and meta-analysis of currently available clinical evidence on migraine and patient foramen ovale percutaneous closure / G. Butera, E. Soulaeva, G. Biondi Zoccai, M. Carminati, L. Caputi, S. Usai, G. Bussone, I. Sheiban, M. Chessa, G. Sangiorgi, G. Meola. ((Intervento presentato al 19. convegno Meeting of the European Neurological Society - ENS tenutosi a Milan nel 2009.

Systematic review and meta-analysis of currently available clinical evidence on migraine and patient foramen ovale percutaneous closure

G. Meola
Ultimo
2009

Abstract

Background and Objectives: In recent years, a potential relationship between, migraine, stroke and patent foramen ovale (PFO) has emerged. We aimed to investigate the role of transcatheter closure of interatrial septal abnormalities on the occurrence of migraine. Methods: BioMedCentral, Google Scholar and PubMed from January 2000 to December 2008 were systematically searched for pertinent clinical studies. Secondary sources were also used. Secondary prevention studies of transcatheter closure for patent foramen ovale were required to include at least more than 10 patients followed for more than 6 months. The primary end-point was the rate of cured or significantly improved migraine after percutaneous PFO closure. Results: After excluding 634 citations, we finally included a total of 14 studies for a total of 1,434 patients. Forty-two percent of the subjects included suffered from migraine, while most had a previous history of transient ischemic attack/stroke and were investigated retrospectively. Quantitative synthesis showed that complete cure of migraine 47.7% (95% CI 30–66%), while resolution or significant improvement of migraine occurred in 76 % (95% C.I. 65.6–86.5 %) of cases. Conclusions: Notwithstanding the limitations inherent in the primary studies, this systematic review suggests that a significant group of subjects with migraine, in particular if treated after a neurological event, may benefit from percutaneous closure of their interatrial septal defect. However, many questions remain un-solved.
23-giu-2009
migraine ; forame ovale
Settore MED/26 - Neurologia
Settore MED/11 - Malattie dell'Apparato Cardiovascolare
Systematic review and meta-analysis of currently available clinical evidence on migraine and patient foramen ovale percutaneous closure / G. Butera, E. Soulaeva, G. Biondi Zoccai, M. Carminati, L. Caputi, S. Usai, G. Bussone, I. Sheiban, M. Chessa, G. Sangiorgi, G. Meola. ((Intervento presentato al 19. convegno Meeting of the European Neurological Society - ENS tenutosi a Milan nel 2009.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/146752
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