Electrodes for Deep Brain Stimulation (DBS) provide the unique opportunity to record electrical activity directly from the human basal ganglia. This study aimed to assess whether the electrical activity of the human subthalamus (STN) differs between males and females. Local field potentials (LFPs) were recorded through DBS electrodes (Medtronic model 3389) implanted in the STN of twenty patients with Parkinson’s disease (12 females, 8 males, 35 nuclei). LFPs were recorded at rest, L-DOPA was withdrawn from at least 12 hours. Signals were preamplified and band passed 2–1000 Hz by an analogical amplifier (Cambridge Electronic Design,model 1902) and digitized with sampling rate 2500 Hz. All the data analysis was conducted off-line. The oscillatory activity of the STN was quantified by power spectral analysis implemented by the Matlab software (version 6.5, The Mathworks, Natik, MA, USA). The power spectrum below 45 Hz was calculated using the Welch’s averaged modified periodogram method, dividing the signals into sections of 2048 samples (spectral resolution = 1.2 Hz). To compare data from males and females, LFPs were normalized. Stereotactic coordinates did not differ between the two groups. In contrast, the total power of the signal recorded from the STN was significantly (P < 0.05, Mann-Whitney U-test) higher in females (mean ± SEM) (3.215 ± 0.75 Arbitrary Units (AU)) than in males (1.591 ± 0.32 AU). The difference was not due to the 2–7 Hz frequencies (females 0.612 ± 0.14; males 0.735 ± 0.26, P > 0.05). On the other hand, the power of the alpha rhythm significantly differed in the two groups: females 0.957 ± 0.24, males 0.276 ± 0.048 (P < 0.05). In conclusion, our data demonstrate gender-related differences in the electrical activity at rest of the STN in patients with Parkinson’s disease.
|Titolo:||Gender-related differences in the electrical activity of the subthalamic nucleus: a local field potentials study in Parkinson's disease|
|Autori interni:||PRIORI, ALBERTO|
|Settore Scientifico Disciplinare:||Settore MED/26 - Neurologia|
|Data di pubblicazione:||giu-2005|
|Digital Object Identifier (DOI):||10.1007/s00415-005-0593-6|
|Appare nelle tipologie:||01 - Articolo su periodico|