From adenosine 1,2'-deoxyadenosine 3 and 3'-deoxyadenosine 5 all the acetates were prepared by lipase-catalyzed reactions. Only the acetates with free 5'-hydroxy group were deaminated by adenosine deaminase (ADA), confirming the crucial role of 5'-OH for the enzyme activity.
The action of adenosine deaminase (EC 3.5.4.4.) on adenosine and deoxyadenosine acetates : The crucial role of the 5 '-hydroxy group for the enzyme activity / P. Ciuffreda, S. Casati, E. Santaniello. - In: TETRAHEDRON. - ISSN 0040-4020. - 56:20(2000 May 12), pp. 3239-3243.
The action of adenosine deaminase (EC 3.5.4.4.) on adenosine and deoxyadenosine acetates : The crucial role of the 5 '-hydroxy group for the enzyme activity
P. CiuffredaPrimo
;S. CasatiSecondo
;E. SantanielloUltimo
2000
Abstract
From adenosine 1,2'-deoxyadenosine 3 and 3'-deoxyadenosine 5 all the acetates were prepared by lipase-catalyzed reactions. Only the acetates with free 5'-hydroxy group were deaminated by adenosine deaminase (ADA), confirming the crucial role of 5'-OH for the enzyme activity.
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