In this work we propose new ensemble methods for the hierarchical classification of gene functions. Our methods exploit the hierarchical relationships between the classes in different ways: each ensemble node is trained “locally”, according to its position in the hierarchy; moreover, in the evaluation phase the set of predicted annotations is built so to minimize a global loss function defined over the hierarchy. We also address the problem of sparsity of annotations by introducing a cost-sensitive parameter that allows to control the precision-recall trade-off. Experiments with the model organism S. cerevisiae, using the FunCat taxonomy and seven biomolecular data sets, reveal a significant advantage of our techniques over “flat” and cost-insensitive hierarchical ensembles.
Hierarchical cost-sensitive algorithms for genome-wide gene function prediction / N. Cesa-Bianchi, G. Valentini. - In: JOURNAL OF MACHINE LEARNING RESEARCH. - ISSN 1532-4435. - 8:(2010), pp. 14-29. ((Intervento presentato al 3. convegno International Workshop on Machine Learning in Systems Biology tenutosi a Ljubljana, Slovenia nel 2009.
Hierarchical cost-sensitive algorithms for genome-wide gene function prediction
N. Cesa-BianchiPrimo
;G. ValentiniUltimo
2010
Abstract
In this work we propose new ensemble methods for the hierarchical classification of gene functions. Our methods exploit the hierarchical relationships between the classes in different ways: each ensemble node is trained “locally”, according to its position in the hierarchy; moreover, in the evaluation phase the set of predicted annotations is built so to minimize a global loss function defined over the hierarchy. We also address the problem of sparsity of annotations by introducing a cost-sensitive parameter that allows to control the precision-recall trade-off. Experiments with the model organism S. cerevisiae, using the FunCat taxonomy and seven biomolecular data sets, reveal a significant advantage of our techniques over “flat” and cost-insensitive hierarchical ensembles.Pubblicazioni consigliate
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