Objective: To determine the concentration of amino acids in women receiving the first course of antenatal betamethasone and to evaluate the umbilical venous and arterial amino acid concentrations at the time of elective cesarean section after betamethasone administration. Study Design: Blood samples were collected from 34 pregnant women at risk of premature delivery before and 24 and 48 hours after the first course of betamethasone. In addition, maternal and cord blood samples were collected in 13 women undergoing an elective cesarean section between 24 and 192 hours after betamethasone. Results: Maternal amino acid concentrations were significantly increased after the first dose of betamethasone. Overall total amino nitrogen increased 17.5% 24 hours after betamethasone administration and 20.5% after 48 hours. The concentration of most amino acids was increased both in the umbilical vein and artery after maternal betamethasone administration. Conclusion: The concentration of maternal and fetal amino acids increases significantly after betamethasone administration.

Effect on antenatal betamethasone on maternal and fetal amino acid concentration / A.M. Marconi, V. Mariotti, C. Teng, S. Ronzoni, B. D'Amato, A. Morabito, F.C. Battaglia. - In: AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. - ISSN 0002-9378. - 202:2(2010 Feb), pp. 166.e1-166.e6. [10.1016/j.ajog.2009.10.704]

Effect on antenatal betamethasone on maternal and fetal amino acid concentration

A.M. Marconi
Primo
;
V. Mariotti
Secondo
;
A. Morabito
Penultimo
;
2010

Abstract

Objective: To determine the concentration of amino acids in women receiving the first course of antenatal betamethasone and to evaluate the umbilical venous and arterial amino acid concentrations at the time of elective cesarean section after betamethasone administration. Study Design: Blood samples were collected from 34 pregnant women at risk of premature delivery before and 24 and 48 hours after the first course of betamethasone. In addition, maternal and cord blood samples were collected in 13 women undergoing an elective cesarean section between 24 and 192 hours after betamethasone. Results: Maternal amino acid concentrations were significantly increased after the first dose of betamethasone. Overall total amino nitrogen increased 17.5% 24 hours after betamethasone administration and 20.5% after 48 hours. The concentration of most amino acids was increased both in the umbilical vein and artery after maternal betamethasone administration. Conclusion: The concentration of maternal and fetal amino acids increases significantly after betamethasone administration.
amino acids; antenatal betamethasone; human pregnancy
Settore MED/40 - Ginecologia e Ostetricia
feb-2010
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/140785
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