Aim: To assess the associations between white blood cells (WBC), high sensitive C reactive protein (hs−CRP) and carotid artery intima media thickness (IMT) in an European population of subjects at high cardiovascular risk, and whether this association is modified by gender, latitude and/or cigarette-smoking. Methods: The baseline dataset of the IMPROVE cohort, including 3711 subjects (age range 54-79 years) with at least 3 vascular risk factors, recruited in 7 centers of 5 European countries (Finland, France, Italy, the Netherlands and Sweden) was analyzed. Results: Crude significant correlations between carotid IMT, WBC and hs−CRP were observed. The associations of hs−CRP and WBC with carotid IMT were evident in men, but not in women and both relations showed significant interactions with gender (p<0.05). A further three-way interaction with latitude was identified for hs−CRP (p=0.0009) but not for WBC. In contrast with latitude, smoking habits do not interfere with the relationships between hs−CRP, WBC, gender and carotid IMT. Conclusions: Both leukocytes and hs−CRP are major determinants of carotid IMT in men, but not in women. The sex-specific effect of hs−CRP seems to be additionally influenced by latitude: regardless of smoking habits, women in northern Europe appear to be protected against the pro-atherosclerotic effect of hs−CRP, whereas those in the south do not. Funding: European Project, IMPROVE QLG1-CT-2002-00896

Associations between carotid artery intima media thickness, leukocytes and high sensitive c reactive protein in a high risk european population / E. Tremoli, D. Baldassarre. - In: ATHEROSCLEROSIS SUPPLEMENTS. - ISSN 1567-5688. - 10:2(2009), pp. e74-e74. ((Intervento presentato al 15. convegno International Symposium on Atherosclerosis tenutosi a Boston nel 2009 [10.1016/S1567-5688(09)70081-9].

Associations between carotid artery intima media thickness, leukocytes and high sensitive c reactive protein in a high risk european population

E. Tremoli
Primo
;
D. Baldassarre
Ultimo
2009

Abstract

Aim: To assess the associations between white blood cells (WBC), high sensitive C reactive protein (hs−CRP) and carotid artery intima media thickness (IMT) in an European population of subjects at high cardiovascular risk, and whether this association is modified by gender, latitude and/or cigarette-smoking. Methods: The baseline dataset of the IMPROVE cohort, including 3711 subjects (age range 54-79 years) with at least 3 vascular risk factors, recruited in 7 centers of 5 European countries (Finland, France, Italy, the Netherlands and Sweden) was analyzed. Results: Crude significant correlations between carotid IMT, WBC and hs−CRP were observed. The associations of hs−CRP and WBC with carotid IMT were evident in men, but not in women and both relations showed significant interactions with gender (p<0.05). A further three-way interaction with latitude was identified for hs−CRP (p=0.0009) but not for WBC. In contrast with latitude, smoking habits do not interfere with the relationships between hs−CRP, WBC, gender and carotid IMT. Conclusions: Both leukocytes and hs−CRP are major determinants of carotid IMT in men, but not in women. The sex-specific effect of hs−CRP seems to be additionally influenced by latitude: regardless of smoking habits, women in northern Europe appear to be protected against the pro-atherosclerotic effect of hs−CRP, whereas those in the south do not. Funding: European Project, IMPROVE QLG1-CT-2002-00896
Settore BIO/14 - Farmacologia
2009
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/140712
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 0
social impact