A sensitive and specific method for aconitine extraction from biological samples was developed. Aconitine, the main toxic alkaloid from plants belonging to Aconitum species (family Ranunculaceae), was determined in plant material by an external standard method, and by a standard addition calibration method in biological fluids. Described here is one fatal case and five intoxications of accidental aconitine poisoning following the ingestion of aconite mistaken for an edible grass, Aruncus dioicus (Walt.) Fernald, "mountain asparagus", and Cicerbita alpina (L.) Wallroth. The aconitine content in urine was in the range 2.94 μg/mL (dead patient) - 0.20 μg/mL (surviving patients), which was almost two to four times higher than that in plasma.

Analytical Aspects of Diterpene Alkaloid Poisoning with Monkshood / M.L. Colombo, C. Bugatti, F. Davanzo, A. Persico, C. Ballabio, P. Restani. - In: NATURAL PRODUCT COMMUNICATIONS. - ISSN 1934-578X. - 4:11(2009), pp. 1551-1552.

Analytical Aspects of Diterpene Alkaloid Poisoning with Monkshood

C. Ballabio
Penultimo
;
P. Restani
Ultimo
2009

Abstract

A sensitive and specific method for aconitine extraction from biological samples was developed. Aconitine, the main toxic alkaloid from plants belonging to Aconitum species (family Ranunculaceae), was determined in plant material by an external standard method, and by a standard addition calibration method in biological fluids. Described here is one fatal case and five intoxications of accidental aconitine poisoning following the ingestion of aconite mistaken for an edible grass, Aruncus dioicus (Walt.) Fernald, "mountain asparagus", and Cicerbita alpina (L.) Wallroth. The aconitine content in urine was in the range 2.94 μg/mL (dead patient) - 0.20 μg/mL (surviving patients), which was almost two to four times higher than that in plasma.
Settore BIO/15 - Biologia Farmaceutica
Settore CHIM/10 - Chimica degli Alimenti
2009
http://www.naturalproduct.us/JournalArchive.asp
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/140369
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 9
  • ???jsp.display-item.citation.isi??? 6
social impact