Protozoa exert a strong selective pressure in humans. The selection signatures left by these pathogens can be exploited to identify genetic modulators of infection susceptibility. We show that protozoa diversity in different geographic locations is a good measure of protozoa-driven selective pressure; protozoa diversity captured selection signatures at known malaria resistance loci and identified several selected single nucleotide polymorphisms in immune and hemolytic anemia genes. A genome-wide search enabled us to identify 5180 variants mapping to 1145 genes that are subjected to protozoa-driven selective pressure. We provide a genome-wide estimate of protozoa-driven selective pressure and identify candidate susceptibility genes for protozoa-borne diseases.

The role of protozoa-driven selection in shaping human genetic variability / U. Pozzoli, M. Fumagalli, R.A. Cagliani, G.P. Comi, N. Bresolin, M.S. Clerici, M. Sironi. - In: TRENDS IN GENETICS. - ISSN 0168-9525. - 26:3(2010 Mar), pp. 95-99.

The role of protozoa-driven selection in shaping human genetic variability

R.A. Cagliani;G.P. Comi;N. Bresolin;M.S. Clerici;M. Sironi
2010

Abstract

Protozoa exert a strong selective pressure in humans. The selection signatures left by these pathogens can be exploited to identify genetic modulators of infection susceptibility. We show that protozoa diversity in different geographic locations is a good measure of protozoa-driven selective pressure; protozoa diversity captured selection signatures at known malaria resistance loci and identified several selected single nucleotide polymorphisms in immune and hemolytic anemia genes. A genome-wide search enabled us to identify 5180 variants mapping to 1145 genes that are subjected to protozoa-driven selective pressure. We provide a genome-wide estimate of protozoa-driven selective pressure and identify candidate susceptibility genes for protozoa-borne diseases.
Settore MED/04 - Patologia Generale
mar-2010
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/139941
Citazioni
  • ???jsp.display-item.citation.pmc??? 16
  • Scopus 26
  • ???jsp.display-item.citation.isi??? 26
social impact