VALENZA, MARTA
VALENZA, MARTA
Dipartimento di Bioscienze
A cutting-edge approach based on UHPLC-MS to simultaneously investigate oxysterols and cholesterol precursors in biological samples: Validation in Huntington's disease mouse model
2024 A. Passoni, M. Favagrossa, M. Valenza, G. Birolini, A. Lanno, C. Mariotti, E. Cattaneo, M. Salmona, L. Colombo, R. Bagnati
The translational potential of cholesterol-based therapies for neurological disease
2023 M. Valenza, G. Birolini, E. Cattaneo
Chronic cholesterol administration to the brain supports complete and long-lasting cognitive and motor amelioration in Huntington's disease
2023 G. Birolini, M. Valenza, I. Ottonelli, F. Talpo, L. Minoli, A. Cappelleri, M. Bombaci, C. Caccia, C. Canevari, A. Trucco, V. Leoni, A. Passoni, M. Favagrossa, M.R. Nucera, L. Colombo, S. Paltrinieri, R. Bagnati, J.T. Duskey, R. Caraffi, M.A. Vandelli, F. Taroni, M. Salmona, E. Scanziani, G. Biella, B. Ruozi, G. Tosi, E. Cattaneo
Cholesterol-laden brain-permeable nanoparticles support long-lasting cognitive recovery and motor amelioration in the slow-progressing zQ175DN mouse model of Huntington’s Disease
2022 G. Birolini, M. Valenza, I. Ottonelli, F. Talpo, L. Minoli, A. Cappelleri, M. Bombaci, C. Caccia, V. Leoni, A. Passoni, M. Favagrossa, M.R. Nucera, L. Colombo, S. Paltrinieri, R. Bagnati, J. Thomas Duskey, R. Caraffi, M. Angela Vandelli, F. Taroni, M. Salmona, E. Scanziani, G.R. Biella, B. Ruozi, G.F. Tosi, E. Cattaneo
Nanoparticles for transport across the blood-brain barrier
2022 E. Cattaneo, M. Valenza, G. Birolini, G. Tosi, B. Ruozi, F. Forni, P. Linciano, M.A. Vandelli
Quantitative comparison of the protein corona of nanoparticles with different matrices
2022 I. Ottonelli, J.T. Duskey, F. Genovese, F. Pederzoli, R. Caraffi, M. Valenza, G. Tosi, M.A. Vandelli, B. Ruozi
SREBP2 gene therapy targeting striatal astrocytes ameliorates Huntington's disease phenotypes
2021 G. Birolini, G. Verlengia, F. Talpo, C. Maniezzi, L. Zentilin, M. Giacca, P. Conforti, C. Cordiglieri, C. Caccia, V. Leoni, F. Taroni, G. Biella, M. Simonato, E. Cattaneo, M. Valenza
ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease
2021 F. Cozzolino, E. Vezzoli, C. Cheroni, D. Besusso, P. Conforti, M. Valenza, I. Iacobucci, V. Monaco, G. Birolini, M. Bombaci, A. Falqui, P. Saftig, R.L. Rossi, M. Monti, E. Cattaneo, C. Zuccato
Insights into kinetics, release, and behavioral effects of brain-targeted hybrid nanoparticles for cholesterol delivery in Huntington's disease
2021 G. Birolini, M. Valenza, I. Ottonelli, A. Passoni, M. Favagrossa, J.T. Duskey, M. Bombaci, M.A. Vandelli, L. Colombo, R. Bagnati, C. Caccia, V. Leoni, F. Taroni, F. Forni, B. Ruozi, M. Salmona, G. Tosi, E. Cattaneo
Dose-dependent and disease-modifying effects of striatal infusion of cholesterol in Huntington{\textquotesingle}s disease
2020 G. Birolini, M. Valenza, E. Dipaolo, E. Vezzoli, F. Talpo, C. Maniezzi, C. Caccia, V. Leoni, V.D. Bocchi, P. Conforti, E. Sogne, L. Petricca, C. Cariulo, M. Verani, A. Caricasole, A. Falqui, G.R. Biella, E. Cattaneo
Insights into kinetics, release, and behavioral effects of brain-targeted hybrid nanoparticles for cholesterol delivery in Huntington disease
2020 G. Birolini, M. Valenza, I. Ottonelli, A. Passoni, M. Favagrossa, J. T Duskey, M. Bombaci, M. Angela Vandelli, L. Colombo, R. Bagnati, C. Caccia, V. Leoni, F. Taroni, F. Forni, B. Ruozi, M. Salmona, G. Tosi, E. Cattaneo
SREBP2 delivery to striatal astrocytes normalizes transcription of cholesterol biosynthesis genes and ameliorates pathological features in Huntington’s Disease
2020 G. Birolini, G. Verlengia, F. Talpo, C. Maniezzi, L. Zentilin, M. Giacca, P. Conforti, C. Cordiglieri, C. Caccia, V. Leoni, F. Taroni, G. Biella, M. Simonato, E. Cattaneo, M. Valenza
Efficacy of Cholesterol Nose-to-Brain Delivery for Brain Targeting in Huntington's Disease
2020 A. Passoni, M. Favagrossa, L. Colombo, R. Bagnati, M. Gobbi, L. Diomede, G. Birolini, E. Di Paolo, M. Valenza, E. Cattaneo, M. Salmona
Striatal infusion of cholesterol promotes dose-dependent behavioral benefits and exerts disease-modifying effects in Huntington's disease mice
2020 G. Birolini, M. Valenza, E. Di Paolo, E. Vezzoli, F. Talpo, C. Maniezzi, C. Caccia, V. Leoni, F. Taroni, V.D. Bocchi, P. Conforti, E. Sogne, L. Petricca, C. Cariulo, M. Verani, A. Caricasole, A. Falqui, G. Biella, E. Cattaneo
Connection between astrocytes, cholesterol and synaptic dysfunction in Huntington’s disease
2017 M. Valenza
Early and brain region-specific decrease of de novo cholesterol biosynthesis in Huntington's disease : a cross-validation study in Q175 knock-in mice
2017 M. Shankaran, E. Di Paolo, V. Leoni, C. Caccia, C. Ferrari Bardile, H. Mohammed, S. Di Donato, S. Kwak, D. Marchionini, S. Turner, E. Cattaneo, M. Valenza
L16 Identifying a therapeutic regimen for cholesterol delivery to Huntington’s disease brain
2016 E. Di Paolo, M. Valenza, J.Y. Chen, B. Ruozi, D. Belletti, C. Cepeda, L. Colombo, L. Diomede, A. Cagnotto, M. Salmona, M.S. Levine, G. Tosi, E. Cattaneo
Disruption of astrocyte-neuron cholesterol cross talk affects neuronal function in Huntington's disease
2015 M. Valenza, M. Marullo, E. Di Paolo, E. Cesana, C. Zuccato, G. Biella, E. Cattaneo
Cholesterol-loaded nanoparticles ameliorate synaptic and cognitive function in Huntington's disease mice
2015 M. Valenza, J.Y. Chen, E. Di Paolo, B. Ruozi, D. Belletti, C. Ferrari Bardile, V. Leoni, C. Caccia, E. Brilli, S. Di Donato, M.M. Boido, A. Vercelli, M.A. Vandelli, F. Forni, C. Cepeda, M.S. Levine, G. Tosi, E. Cattaneo
Lack of huntingtin promotes neural stem cells differentiation into glial cells while neurons expressing huntingtin with expanded polyglutamine tracts undergo cell death
2013 P. Conforti, S. Camnasio, C. Mutti, M. Valenza, M. Thompson, E. Fossale, S. Zeitlin, M.E. Macdonald, C. Zuccato, E. Cattaneo