IRIS Institutional Research Information System - AIR Archivio Istituzionale della Ricerca

DE MICHELI, CARLO
 Distribuzione geografica
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Continente #
EU - Europa 9.816
NA - Nord America 7.468
AS - Asia 7.171
SA - Sud America 623
AF - Africa 144
OC - Oceania 26
Continente sconosciuto - Info sul continente non disponibili 11
Totale 25.259
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Nazione #
US - Stati Uniti d'America 7.292
GB - Regno Unito 3.070
SG - Singapore 2.254
CN - Cina 2.113
IT - Italia 1.570
DE - Germania 1.505
RU - Federazione Russa 975
SE - Svezia 892
HK - Hong Kong 610
FR - Francia 426
TR - Turchia 415
IN - India 414
BR - Brasile 392
VN - Vietnam 390
KR - Corea 309
UA - Ucraina 306
IE - Irlanda 274
NL - Olanda 261
BD - Bangladesh 209
FI - Finlandia 186
EU - Europa 172
CA - Canada 109
JP - Giappone 102
CO - Colombia 92
ID - Indonesia 70
PH - Filippine 69
ES - Italia 56
GR - Grecia 54
AR - Argentina 49
CI - Costa d'Avorio 44
BE - Belgio 38
IQ - Iraq 37
DK - Danimarca 35
PL - Polonia 34
MX - Messico 30
PK - Pakistan 28
AU - Australia 25
EC - Ecuador 23
CH - Svizzera 22
ZA - Sudafrica 22
CL - Cile 19
RO - Romania 19
VE - Venezuela 19
SA - Arabia Saudita 17
AT - Austria 16
IR - Iran 16
MY - Malesia 15
UZ - Uzbekistan 15
EG - Egitto 14
MA - Marocco 14
KE - Kenya 13
JO - Giordania 11
NO - Norvegia 11
NP - Nepal 10
TH - Thailandia 10
TW - Taiwan 10
HU - Ungheria 9
PE - Perù 9
PY - Paraguay 9
AL - Albania 8
UY - Uruguay 8
DZ - Algeria 7
HN - Honduras 6
JM - Giamaica 6
PT - Portogallo 6
AE - Emirati Arabi Uniti 5
CR - Costa Rica 5
CZ - Repubblica Ceca 5
LT - Lituania 5
NG - Nigeria 5
AM - Armenia 4
AZ - Azerbaigian 4
DO - Repubblica Dominicana 4
EE - Estonia 4
ET - Etiopia 4
LV - Lettonia 4
PR - Porto Rico 4
BA - Bosnia-Erzegovina 3
BB - Barbados 3
BG - Bulgaria 3
BH - Bahrain 3
BO - Bolivia 3
GH - Ghana 3
IL - Israele 3
LU - Lussemburgo 3
MK - Macedonia 3
MM - Myanmar 3
TN - Tunisia 3
TT - Trinidad e Tobago 3
A2 - ???statistics.table.value.countryCode.A2??? 2
AF - Afghanistan, Repubblica islamica di 2
AO - Angola 2
BY - Bielorussia 2
GE - Georgia 2
KG - Kirghizistan 2
KZ - Kazakistan 2
LK - Sri Lanka 2
LY - Libia 2
MD - Moldavia 2
MU - Mauritius 2
Totale 25.382
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Città #
Southend 2.837
Singapore 1.257
Ashburn 583
Hong Kong 574
Hanover 568
Milan 546
Chandler 543
San Jose 485
Seattle 480
Beijing 446
Princeton 389
Wilmington 310
Santa Clara 287
Council Bluffs 278
Dublin 270
Dallas 246
Mountain View 223
Ann Arbor 216
Redmond 211
Nanjing 175
Fairfield 172
Dearborn 160
Munich 160
Jacksonville 159
Los Angeles 152
Lauterbourg 147
Woodbridge 135
Sakarya 130
Bengaluru 128
Frankfurt am Main 126
New York 113
Guangzhou 109
Ho Chi Minh City 109
Moscow 105
Boardman 99
Buffalo 99
Somerville 98
Hanoi 97
Des Moines 92
Houston 92
Jinan 83
Shanghai 78
Serra 77
Bogotá 70
Tokyo 70
Andover 68
Shenyang 66
Cangzhou 60
Tianjin 58
Phoenix 55
Redwood City 53
Toronto 51
Athens 50
Cambridge 50
Hefei 48
Nanchang 48
The Dalles 45
Abidjan 44
Columbus 43
Eitensheim 40
Hebei 37
Rome 37
Changsha 34
Hamburg 32
Medford 32
Brussels 31
Naples 31
Berlin 30
Grafing 30
Mumbai 30
Seoul 30
Jakarta 28
Odernheim 28
São Paulo 28
Helsinki 27
Hangzhou 25
Zhengzhou 25
Shenzhen 24
Fuzhou 22
Kyiv 22
Atlanta 21
Ningbo 21
San Diego 20
Bitonto 19
Haiphong 19
Kunming 19
Norwalk 19
Wuhan 19
Jiaxing 18
Murcia 17
Orem 17
Auburn Hills 16
Chicago 16
Genoa 16
Warsaw 16
Florence 15
Nürnberg 15
Baghdad 14
Bühl 14
London 14
Totale 15.491
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Nome #
Agonisti nicotinici selettivi nel trattamento di patologie del Sistema Nervoso Centrale 598
Folates in Trypanosoma brucei: achievements and opportunities 345
Structural basis of subunit-selectivity for competitive NMDA receptor antagonists with preference for GluN2A over GluN2B subunits 306
Synthesis and pharmacological characterization at glutamate receptors of erythro- and threo-tricholomic acid and homologues thereof 281
Efficient synthesis of kainic acid analogues 277
γ-Glutamyl-dipeptides : Easy tools to rapidly probe the stereoelectronic properties of the ionotropic glutamate receptor binding pocket 276
Chemoenzymatic synthesis in flow reactors: a rapid and convenient preparation of Captopril 267
Orthosteric and allosteric ligands selectively acting at cholinergic receptor subtypes 254
3-Carboxy-pyrazolinalanine as a new scaffold for developing potent and selective NMDA receptor antagonists 254
Synthesis of epibatidine-related Delta(2)-isoxazoline derivatives and evaluation of their binding affinity at neuronal nicotinic acetylcholine receptors 250
Synthesis and structure-activity relationships in a set of new antimuscarinic agents 249
Design, Synthesis, and Pharmacological Characterization of Novel Spirocyclic Quinuclidinyl-Δ2-Isoxazoline Derivatives as Potent and Selective Agonists of α7 Nicotinic Acetylcholine Receptors 243
Neuroprotective effects of the novel glutamate transporter inhibitor (-)-3-hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-4-carboxylic acid, which preferentially inhibits reverse transport (glutamate release) compared with glutamate reuptake 242
Synthesis and pharmacological evaluation of novel conformationally constrained homologues of glutamic acid 235
Synthesis of novel chiral Δ2-isoxazoline derivatives related to ABT-418 and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes 234
Synthesis of unusual isoxazoline containing β and γ-dipeptides as potential glutamate receptor ligands 234
Synthesis of enantiomerically pure HIP-A and HIP-B and investigation of their activity as inhibitors of excitatory amino acid transporters 229
Bicyclic γ-amino acids as inhibitors of γ-aminobutyrate aminotransferase 228
CTP synthetase inhibitors as new potential agents for the treatment of African Trypanosomiasis : synthesis and in vitro/in vivo evaluation of trypanocidal activity of 3-Br-Acivicin 226
Efficient synthesis of novel glutamate homologues and investigation of their affinity and selectivity profile at ionotropic glutamate receptors 226
Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity 225
The impact of Chirality on Medicinal Chemistry 224
A regioselective route to 5-substituted pyrazole- and pyrazoline-3-phosphonic acids and esters 224
Synthesis, Binding Affinity at Glutamic Acid Receptors, Neuroprotective Effects, and Molecular Modeling Investigation of Novel Dihydroisoxazole Amino Acids 223
Synthesis and binding affinity at α4β2 and α7 nicotinic acetylcholine receptors of new analogs of epibatidine and epiboxidine containing the 7-azabicyclo[2.2.1]hept-2-ene ring system 218
Design of Cyclopentaisoxazoline Amino Acids as Conformationally Constrained Agonists at Glutamate Receptors 214
The enantiomers of epiboxidine and of two related analogs: Synthesis and estimation of their binding affinity at α4β2 and α7 neuronal nicotinic acetylcholine receptors 213
Synthesis and Anticonvulsant Activity of Novel Bicyclic Acidic Amino Acids 212
Engineering of α-conotoxin MII-derived peptides with increased selectivity for native α6β2* nicotinic acetylcholine receptors 212
COMPUTATIONAL INVESTIGATION ON SUBSTRATE UPTAKE AND RELEASE IN A GLUTAMATE TRANSPORTER 211
New spirocyclic Δ2-isoxazoline derivatives related to selective agonists of α7 neuronal nicotinic acetylcholine receptors 210
Alpha7 nAChR: pathogenesis and treatment of chemotherapy-induced neuropathy 210
Flow-based biocatalysis : application to peracetylated arabinofuranosyl-1,5-arabinofuranose synthesis 206
Nuovi ligandi nicotinici correlati all'Epibatidina e all'Epibossidina: sintesi e valutazione della loro affinità per i recettori nicotinici neuronali alpha4beta2 e alpha7 205
Synthesis of novel pyrrolo[3,4-d]pyrazole-dicarboxylic acids and evaluation of their interaction with glutamate receptors 202
Regioselective Preparation of Functionalized Isoxazoline Derivatives, Key Intermediates in the Synthesis of Selective NMDA Receptor Antagonists 202
Alpha7 nicotinic acetylcholine receptor agonists: prediction of their binding affinity through a molecular mechanics poisson-boltzmann surface area approach 201
Synthesis and pharmacological characterization at glutamate receptors of the four enantiopure isomers of tricholomic acid 201
Chemotherapy-induced neuropathy: involvement of the alpha7 nAChR subtype 201
The enantiomers of epiboxidine: synthesis and binding affinity at neuronal nicotinic acetylcholine receptor subtypes 200
Synthesis of L-tricholomic acid analogues and pharmacological characterization at ionotropic glutamate receptors 200
Novel spirocyclic delta2-isoxazoline derivatives as lower homologues of selective agonists for neuronal alpha-7 nicotinic acetylcholine receptor subtypes 195
Discovery of covalent inhibitors of glyceraldehyde-3-phosphate dehydrogenase, a target for the treatment of malaria 195
Synthesis and in vitro/in vivo Evaluation of the Antitrypanosomal Activity of 3-Bromoacivicin, a Potent CTP Synthetase Inhibitor 193
Synthesis of enantiopure Delta(2)-isoxazoline derivatives and evaluation of their affinity and efficacy profiles at human beta-adrenergic receptor subtypes 184
Design and synthesis of novel isoxazole-based HDAC inhibitors 184
Design, synthesis and biological characterization of PfGAPDH inhibitors 183
Effects of 3-bromo-4,5-dihydroisoxazole derivatives on Nrf2 activation and heme oxygenase-1 expression 180
Synthesis of pyrrol-3-yl-ethanolamines 179
Synthesis of novel enantiopure 2-isoxazoline and 2-pyrazoline amino acids and their activity at glutamic acid receptors and transporters 178
Synthesis of new Delta(2)-isoxazoline derivatives and their pharmacological characterization as beta-adrenergic receptor antagonists 178
Development of Radiolabeled Ligands Targeting the Glutamate Binding Site of the N-Methyl-d-aspartate Receptor as Potential Imaging Agents for Brain 178
Design of Novel Conformationally Restricted Analogues of Glutamic Acid 177
Synthesis of novel epibatidine-related derivatives through 1,3-dipolar cycloaddition of pyridinenitrile oxides 176
A new synthesis of (D,L)-muscarone via 1,3-dipolar cycloaddition 176
Synthesis and Biological Evaluation of CTP Synthetase Inhibitors as Potential Agents for the Treatment of African Trypanosomiasis 176
1-Aryl-6,7-methylenedioxy-3H-quinazolin-4-ones as anticonvulsant agents 175
Development of a Three-Dimensional Model for the N-Methyl-D-aspartate NR2A Subunit 172
Inhibition of Rhodesain as a Novel Therapeutic Modality for Human African Trypanosomiasis 172
Synthesis and pharmacological characterization of new analogs of broxaterol 172
Design, synthesis, and pharmacological characterization of novel, potent NMDA receptor antagonists 171
SYNTHESIS AND PHARMACOLOGICAL INVESTIGATION OF THE 3-ANALOGS OF VIMINOL 170
Novel chiral isoxazole derivatives: synthesis and pharmacological characterization at human b-adrenergic receptor subtypes 169
Synthesis of Conformationally Constrained Glutamic Acid Homologues and Investigation of Their Pharmacological Profiles 168
Nicotinic agonists selective for the Alpha7 Receptor Subtype, the process for their preparation thereof and pharmaceutical compositions therefrom 167
A regioselective route to 5-substituted isoxazoline-3-phosphonates 164
SYNTHESIS AND PHARMACOLOGICAL INVESTIGATION OF STEREOISOMERIC MUSCARINES 163
Metadynamic investigations of the aspartate binding at glutamate transporters 162
Progettazione e sintesi di analoghi strutturali dell’Epibossodina 161
SYNTHESIS AND PHARMACOLOGICAL INVESTIGATION OF CHOLINERGIC LIGANDS STRUCTURALLY RELATED TO MUSCARONE 161
Relative potencies of the stereoisomers of bethanechol on muscarinic receptor 161
Synthesis and biological evaluation of papain-family cathepsinl-like cysteine protease inhibitors containing a 1,4-benzodiazepine scaffold as antiprotozoal agents 161
METAL-HYDRIDE REDUCTION OF ISOXAZOLINE-3-CARBOXYLATE ESTERS 160
A chemoenzymatic approach to the synthesis of the stereoisomers of a beta-adrenergic receptor antagonist 157
Pharmacological profile of enantiomerically pure chiral muscarinic agonists - Desoxymuscarines 157
Novel Bifunctional Compounds Targeting Nicotine and Dopamine Receptor Subtypes: Synthesis and Pharmacological Investigation 157
Inspired by Nature : The 3-Halo-4,5-dihydroisoxazole Moiety as a Novel Molecular Warhead for the Design of Covalent Inhibitors 156
AN EASY SYNTHESIS OF DIHYDROMUSCIMOL 154
Design of 1-substituted 2-arylmethyl-4,5-methylene-dioxybenzene derivatives as antiseizure agents 152
Selective nicotinic agonists to treat pathologies of the central nervous system 152
Chemoenzymatic synthesis of the enantiomers of desoxymuscarine 151
Dissociation of [3H]L-Glutamate Uptake from L-Glutamate-Induced [3H]D-Aspartate release by 3-Hydroxy-4,5,6,6atetrahydro-3aH-pyrrolo[3,4-d]isoxazole-4-carboxylic Acid and 3-Hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-6-carboxylic Acid, Two Conf 150
New 7,8-ethylenedioxy-2,3-benzodiazepines as noncompetitive AMPA receptor antagonists 150
Stereoselective synthesis of 4-amino-3-hydroxy-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxazole-4-carboxylic acid, a conformationally constrained analogue of aspartic acid 149
beta(3)-adrenergic receptor ligands: insight into structure-activity relationships using Monte-Carlo conformational analysis in water 149
Synthesis of TBOA homologues and evaluation of their activity as Glutamate transporter inhibitors 147
CHEMOENZYMATIC SYNTHESIS OF THE 8 STEREOISOMERIC MUSCARINES 147
AN EFFICIENT SYNTHESIS OF ISOXAZOLES AND ISOXAZOLINES 147
Enantiomeric forms of (±)-HIP-A and (±)-HIP-B : synthesis and evalutation of their activity at the excitatory amino acids 146
Synthesis and Pharmacological Evaluation of (42) Nicotinic Ligands with a 3-Fluoropyrrolidine Nucleus 146
Synthesis of new β- and γ-benzyloxy-S-glutamic acid derivatives and evaluation of their activity as inhibitors of excitatory amino acid transporters 145
Synthesis of 3-benzenesulfonylisoxazolines and isoxazolidines 145
Synthesis of 3-hydroxy- and 3-carboxy-Delta(2)-isoxazoline amino acids and evaluation of their interaction with GABA receptors and transporters 144
Synthesis and binding affinity of new muscarinic ligands structurally related to oxotremorine 143
Synthesis of new isoxazoline-based acidic amino acids and investigation of their affinity and selectivity profile at ionotropic glutamate receptors 141
Mechanism of falcipain-2 inhibition by α,β-unsaturated benzo[1,4]diazepin-2-one methyl ester 141
Development of Rhodesain Inhibitors with a 3-Bromoisoxazoline Warhead 141
Synthesis and biological evaluation of new ligands designed to selectively interact with kainate receptors 141
Synthesis of (3-hydroxy-pyrazolin-5-yl)glycine based ligands interacting with ionotropic glutamate receptors 140
A highly efficient flow reactor process for the synthesis of N-Boc-3,4-dehydro-L-proline methyl ester 139
Totale 19.416
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Categoria #
all - tutte 71.773
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 71.773
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021631 0 0 0 0 0 0 0 0 0 0 484 147
2021/20222.336 174 39 69 62 146 468 418 111 118 204 237 290
2022/20232.133 303 183 196 242 246 443 39 124 216 27 85 29
2023/20241.212 38 112 57 47 278 83 77 65 27 69 182 177
2024/20253.239 127 318 68 369 333 112 82 413 149 237 227 804
2025/20266.371 586 374 740 565 716 472 705 456 720 510 527 0
Totale 26.944