Sfoglia per Autore
Flavodoxin-cytochrome c interactions : circular dichroism and nuclear magnetic resonance studies
1987 G. Tollin, K. Brown, R. De Francesco, D.E. Edmondson
Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: a 2.2 A resolution structure in a hexagonal crystal form
1998 Y. Yan, L. Ying, S. Munshi, V. Sardana, J.L. Cole, M. Sardana, L.C. Kuo, Z. Chen, C. Steinkuehler, L. Tomei, R.D. Francesco
Characterization of the Inhibition of Hepatitis C Virus RNA Replication by Nonnucleosides
2004 L. Tomei, S. Altamura, L. Bartholomew, M. Bisbocci, C. Bailey, M. Bosserman, A. Cellucci, E. Forte, I. Incitti, L. Orsatti, U. Koch, R. De Francesco, D.B. Olsen, S.S. Carroll, G. Migliaccio
The monoethyl ester of meconic acid is an active site inhibitor of HCV NS5B RNA-dependent RNA polymerase
2004 P. Pace, E. Nizi, B. Pacini, S. Pesci, V. Matassa, R. De Francesco, S. Altamura, V. Summa
HCVNS5b RNA-dependent RNA polymerase inhibitors: From alpha,gamma-diketoacids to 4,5-dihydroxypyrimidine- or 3-methyl-5-hydroxypyrimidinonecarboxylic acids : design and synthesis
2004 V. Summa, A. Petrocchi, V.G. Matassa, M. Taliani, R. Laufer, R. De Francesco, S. Altamura, P. Pace
Reduction of hepatitis C virus NS5A hyperphosphorylation by selective inhibition of cellular kinases activates viral RNA replication in cell culture
2004 P. Neddermann, M. Quintavalle, C. Di Pietro, A. Clementi, M. Cerretani, S. Altamura, L. Bartholomew, R. De Francesco
Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor
2004 A. Vannini, C. Volpari, G. Filocamo, E.C. Casavola, M. Brunetti, D. Renzoni, P. Chakravarty, C. Paolini, R. De Francesco, P. Gallinari, C. Steinkühler, S. Di Marco
Discovery of alpha,gamma-diketo acids as potent selective and reversible inhibitors of hepatitis C virus NS5b RNA-dependent RNA polymerase
2004 V. Summa, A. Petrocchi, P. Pace, V.G. Matassa, R. De Francesco, S. Altamura, L. Tomei, U. Koch, P. Neuner
Challenges and successes in developing new therapies for hepatitis C
2005 R. De Francesco, G. Migliaccio
Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site
2005 S. Di Marco, C. Volpari, L. Tomei, S. Altamura, S. Harper, F. Narjes, U. Koch, M. Rowley, R. De Francesco, G. Migliaccio, A. Carfí
A functionally orthogonal estrogen receptor-based transcription switch specifically induced by a nonsteroid synthetic ligand
2005 P. Gallinari, A. Lahm, U. Koch, C. Paolini, M.C. Nardi, G. Roscilli, O. Kinzel, D. Fattori, E. Muraglia, C. Toniatti, R. Cortese, R. De Francesco, G. Ciliberto
HCV antiviral resistance: The impact of in vitro studies on the development of antiviral agents targeting the viral NS5B polymerase
2005 L. Tomei, S. Altamura, G. Paonessa, R. De Francesco, G. Migliaccio
Potent inhibitors of subgenomic hepatitis C virus RNA replication through optimization of indole-N-acetamide allosteric inhibitors of the viral NS5B polymerase
2005 S. Harper, S. Avolio, B. Pacini, M. Di Filippo, S. Altamura, L. Tomei, G. Paonessa, S. Di Marco, A. Carfi, C. Giuliano, J. Padron, F. Bonelli, G. Migliaccio, R. De Francesco, R. Laufer, M. Rowley, F. Narjes
Development and preliminary optimization of indole-N-acetamide inhibitors of hepatitis C virus NS5B polymerase
2005 S. Harper, B. Pacini, S. Avolio, M. Di Filippo, G. Migliaccio, R. Laufer, R. De Francesco, M. Rowley, F. Narjes
A series of novel, potent, and selective histone deacetylase inhibitors
2006 P. Jones, S. Altamura, P.K. Chakravarty, O. Cecchetti, R.D. Francesco, P. Gallinari, R. Ingenito, P.T. Meinke, A. Petrocchi, M. Rowley, R. Scarpelli, S. Serafini, C. Steinkühler
2-(2-thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: Discovery, SAR, modeling, and mutagenesis
2006 U. Koch, B. Attenni, S. Malancona, S. Colarusso, I. Conte, M. Di Filippo, S. Harper, B. Pacini, C. Giomini, S. Thomas, I. Incitti, L. Tomei, R. De Francesco, S. Altamura, V.G. Matassa, F. Narjes
The alpha isoform of protein kinase CKI is responsible for hepatitis C virus NS5A hyperphosphorylation
2006 M. Quintavalle, S. Sambucini, C. Di Pietro, R. De Francesco, P. Neddermann
A structure-guided approach to an orthogonal estrogen-receptor-based gene switch activated by ligands suitable for in vivo studies
2006 O. Kinzel, D. Fattori, E. Muraglia, P. Gallinari, M.C. Nardi, C. Paolini, G. Roscilli, C. Toniatti, O. Gonzalez Paz, R. Laufer, A. Lahm, A. Tramontano, R. Cortese, R. De Francesco, G. Ciliberto, U. Koch
Advances in the development of new therapeutic agents targeting the NS3-4A serine protease or the NS5B RNA-dependent RNA polymerase of the hepatitis C virus
2007 R. De Francesco, A. Carfí
Effects of pH and low density lipoprotein (LDL) on PCSK9-dependent LDL receptor regulation
2007 T.S. Fisher, P.L. Surdo, S. Pandit, M. Mattu, J.C. Santoro, D. Wisniewski, R.T. Cummings, A. Calzetta, R.M. Cubbon, P.A. Fischer, A. Tarachandani, R. De Francesco, S.D. Wright, C.P. Sparrow, A. Carfi, A. Sitlani
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