The present invention relates to new cellular peptides permeable to cell membranes capable of interfering with CAP2/actin association and inhibiting the endocytosis of the ADAM10 enzyme. Also contemplated are pharmaceutical compositions comprising the endocytosis inhibitory peptides of ADAM10 and the related uses in the medical field for the treatment and/or prevention of pathologies in which an increase or accumulation of the beta-amyloid peptide occurs, such for example Alzheimer's Disease, head injury and post-traumatic stress disorder.
Peptidi inibitori dell'endocitosi di ADAM10 e relativi usi nel trattamento della malattia di Alzheimer / E. Marcello, M. Di Luca, S. Pelucchi, L. Vandermeulen, F. Gardoni, D. Di Marino.
Peptidi inibitori dell'endocitosi di ADAM10 e relativi usi nel trattamento della malattia di Alzheimer
E. Marcello;M. Di Luca;S. Pelucchi;L. Vandermeulen;F. Gardoni;
2021
Abstract
The present invention relates to new cellular peptides permeable to cell membranes capable of interfering with CAP2/actin association and inhibiting the endocytosis of the ADAM10 enzyme. Also contemplated are pharmaceutical compositions comprising the endocytosis inhibitory peptides of ADAM10 and the related uses in the medical field for the treatment and/or prevention of pathologies in which an increase or accumulation of the beta-amyloid peptide occurs, such for example Alzheimer's Disease, head injury and post-traumatic stress disorder.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
