A family of neutral bis-cyclometalated Ir(III) complexes based on phenanthridine (phent) derivates as cyclometalating ligands and picolinate as an ancillary ligand are described. The influence of extended conjugation, rigidity, and hydrophobicity as well as the electronic nature of the substituents were investigated in relation to the photoluminescence, PL, and electrochemiluminescence, ECL, properties. A significant increase of ECL in aqueous media is observed upon extension of the aromatic system or by substituting the phenyl with a dibenzofurane moiety, in compounds 2 and 3, respectively. Under real immunoassay conditions, these complexes achieve up to 4-fold higher ECL efficiency than the commercial ruthenium standard. These values, among the highest reported in the literature under these conditions, confirm the potential of iridium complexes as alternative labels in commercial instruments.
Ir(III) Cyclometalated Complexes Containing Phenylphenanthridine Ligands with Different Substitutions : Effects on the Electrochemiluminescence Properties / E. Longhi, J.M. Fernandez-Hernandez, A. Iordache, R. Frohlich, H.P. Josel, L. De Cola. - In: INORGANIC CHEMISTRY. - ISSN 0020-1669. - 59:11(2020), pp. 7435-7443. [10.1021/acs.inorgchem.0c00107]
Ir(III) Cyclometalated Complexes Containing Phenylphenanthridine Ligands with Different Substitutions : Effects on the Electrochemiluminescence Properties
L. De Cola
2020
Abstract
A family of neutral bis-cyclometalated Ir(III) complexes based on phenanthridine (phent) derivates as cyclometalating ligands and picolinate as an ancillary ligand are described. The influence of extended conjugation, rigidity, and hydrophobicity as well as the electronic nature of the substituents were investigated in relation to the photoluminescence, PL, and electrochemiluminescence, ECL, properties. A significant increase of ECL in aqueous media is observed upon extension of the aromatic system or by substituting the phenyl with a dibenzofurane moiety, in compounds 2 and 3, respectively. Under real immunoassay conditions, these complexes achieve up to 4-fold higher ECL efficiency than the commercial ruthenium standard. These values, among the highest reported in the literature under these conditions, confirm the potential of iridium complexes as alternative labels in commercial instruments.File | Dimensione | Formato | |
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