S-adenosylmethionine supplies methyl groups to many acceptors, including lipids, proteins, RNA, DNA, and a wide range of small molecules. It acts as the precursor in the biosynthesis of metal ion chelating compounds, such as nicotianamine and phytosiderophores, of the polyamines spermidine and spermine and of some plant hormones. Finally, it is the source of catalytic 5′-deoxyadenosyl radicals. Radical S-adenosylmethionine (SAM) enzymes (RS) represent one of the most abundant groups (more than 100,000) of enzymes, exerting a plethora of biological functions, some of which are still unknown. In this work, we will focus on two RS: CDK5RAP1 and CDKAL1, both of which are involved in tRNA modifications that result in important tRNA folding and stability and in maintaining high translational fidelity. Based on this crucial role, their impairment can be important in the development of different human diseases.

S-adenosylmethionine trna modification: Unexpected/unsuspected implications of former/new players / R. Adami, D. Bottai. - In: INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES. - ISSN 1449-2288. - 16:15(2020), pp. 3018-3027. [10.7150/ijbs.49302]

S-adenosylmethionine trna modification: Unexpected/unsuspected implications of former/new players

R. Adami
Primo
;
D. Bottai
Ultimo
2020

Abstract

S-adenosylmethionine supplies methyl groups to many acceptors, including lipids, proteins, RNA, DNA, and a wide range of small molecules. It acts as the precursor in the biosynthesis of metal ion chelating compounds, such as nicotianamine and phytosiderophores, of the polyamines spermidine and spermine and of some plant hormones. Finally, it is the source of catalytic 5′-deoxyadenosyl radicals. Radical S-adenosylmethionine (SAM) enzymes (RS) represent one of the most abundant groups (more than 100,000) of enzymes, exerting a plethora of biological functions, some of which are still unknown. In this work, we will focus on two RS: CDK5RAP1 and CDKAL1, both of which are involved in tRNA modifications that result in important tRNA folding and stability and in maintaining high translational fidelity. Based on this crucial role, their impairment can be important in the development of different human diseases.
CDK5RAP1; CDKAL1; Human diseases; Methylthiotransferases; Radical S-adenosylmethionine enzymes; TRNA modifications
Settore BIO/09 - Fisiologia
Settore BIO/13 - Biologia Applicata
Settore BIO/14 - Farmacologia
Settore BIO/10 - Biochimica
Settore BIO/11 - Biologia Molecolare
2020
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/781868
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