Introduction: In this study we estimated the rate and the trajectory of cognitive impairment in a naturalistic sample of outpatients with major depressive disorder (MDD) and bipolar disorder (BD) and its correlation with different variables. Materials and methods: An overall sample of 109 outpatients with MDD or BD was assessed for multiple clinical variables, including duration of untreated illness (DUI), and tested using the Montreal Cognitive Assessment (MoCA) during Major Depressive Episodes (MDE) and after remission. Correlations between MoCA scores and the clinical variables were then computed. Results: About 50% of patients with MDD and BD showed mild cognitive impairment during MDE. Improvement of cognitive function between depression and remission was significant, even though residual symptoms were observed especially in the most impaired patients. Of note, cognitive performance during depression was negatively associated with depression severity and DUI. Discussion: Present findings confirm available evidence about patterns of cognitive impairment in mood disorders, in terms of prevalence and persistence beyond remission in most severe cases. Moreover, a longer DUI was associated with worse cognitive performance during depression, and consequently with poorer outcome, underlining the importance of prompt treatment of these disorders also in light of a cognitive perspective. Keywords: bipolar disorder, cognitive dysfunction, duration of untreated illness, major depressive disorder, Montreal cognitive assessment

Duration of untreated illness and depression severity are associated with cognitive impairment in mood disorders / C. Galimberti, M.F. Bosi, M. Volontè, F. Giordano, B.M. Dell'Osso, V. Caterina. - In: INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE. - ISSN 1365-1501. - (2020). [Epub ahead of print] [10.1080/13651501.2020.1757116]

Duration of untreated illness and depression severity are associated with cognitive impairment in mood disorders

M.F. Bosi
Secondo
Membro del Collaboration Group
;
B.M. Dell'Osso
Penultimo
;
V. Caterina
Ultimo
2020

Abstract

Introduction: In this study we estimated the rate and the trajectory of cognitive impairment in a naturalistic sample of outpatients with major depressive disorder (MDD) and bipolar disorder (BD) and its correlation with different variables. Materials and methods: An overall sample of 109 outpatients with MDD or BD was assessed for multiple clinical variables, including duration of untreated illness (DUI), and tested using the Montreal Cognitive Assessment (MoCA) during Major Depressive Episodes (MDE) and after remission. Correlations between MoCA scores and the clinical variables were then computed. Results: About 50% of patients with MDD and BD showed mild cognitive impairment during MDE. Improvement of cognitive function between depression and remission was significant, even though residual symptoms were observed especially in the most impaired patients. Of note, cognitive performance during depression was negatively associated with depression severity and DUI. Discussion: Present findings confirm available evidence about patterns of cognitive impairment in mood disorders, in terms of prevalence and persistence beyond remission in most severe cases. Moreover, a longer DUI was associated with worse cognitive performance during depression, and consequently with poorer outcome, underlining the importance of prompt treatment of these disorders also in light of a cognitive perspective. Keywords: bipolar disorder, cognitive dysfunction, duration of untreated illness, major depressive disorder, Montreal cognitive assessment
bipolar disorders, cognitive dysfunction, duration untreated illness, major depressive disorder
Settore MED/25 - Psichiatria
2020
27-apr-2020
Article (author)
File in questo prodotto:
File Dimensione Formato  
Galimberti DUI and MOCA IJPCP.pdf

accesso aperto

Tipologia: Pre-print (manoscritto inviato all'editore)
Dimensione 412.36 kB
Formato Adobe PDF
412.36 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/738100
Citazioni
  • ???jsp.display-item.citation.pmc??? 7
  • Scopus 31
  • ???jsp.display-item.citation.isi??? 28
social impact