Pasteurized donor human milk (PDHM) for preterm infant nutrition is fortified with hydrolyzates of cow’s milk proteins, which have been poorly investigated in relation to heat-damage and occurrence of the bioactive peptides β-casomorphins (BCMs). Therefore, thermal protein modifications of three commercial fortifiers were assessed by measuring well-recognized indexes of heat load. The fortifiers did not contain pyrraline, whereas furosine and lysinoalanine levels roughly overlapped the lowest values reported for liquid formulas addressed to term infant nutrition. Bovine BCMs 3 to 7 and human BCMs 3 to 9 were searched. Bovine BCMs 3, 4, 6 and 7 were found in the undigested fortifiers. Following in vitro digestion simulating the digestive conditions of pre- mature infant, bovine BCMs still occurred in fortified PDHM; the human BCMs 3, 7, 8 and 9 formed. Overall, these results better address the nutritional features of protein fortifiers and fortified PDHM intended for nutrition of preterm infants.

Effect of protein fortification on heat damage and occurrence of beta-casomorphins in (un)digested donor human milk intended for nutrition of preterm infants / S. Cattaneo, V. Pica, M. Stuknytė, F. Masotti, D. Mallardi, C. Tabasso, P. Roggero, I. De Noni. - In: FOOD CHEMISTRY. - ISSN 0308-8146. - 314(2020 Jun 01), pp. 126176.1-126176.8. [10.1016/j.foodchem.2020.126176]

Effect of protein fortification on heat damage and occurrence of beta-casomorphins in (un)digested donor human milk intended for nutrition of preterm infants

S. Cattaneo
Primo
;
V. Pica
Secondo
;
M. Stuknytė;F. Masotti;C. Tabasso;I. De Noni
Ultimo
2020

Abstract

Pasteurized donor human milk (PDHM) for preterm infant nutrition is fortified with hydrolyzates of cow’s milk proteins, which have been poorly investigated in relation to heat-damage and occurrence of the bioactive peptides β-casomorphins (BCMs). Therefore, thermal protein modifications of three commercial fortifiers were assessed by measuring well-recognized indexes of heat load. The fortifiers did not contain pyrraline, whereas furosine and lysinoalanine levels roughly overlapped the lowest values reported for liquid formulas addressed to term infant nutrition. Bovine BCMs 3 to 7 and human BCMs 3 to 9 were searched. Bovine BCMs 3, 4, 6 and 7 were found in the undigested fortifiers. Following in vitro digestion simulating the digestive conditions of pre- mature infant, bovine BCMs still occurred in fortified PDHM; the human BCMs 3, 7, 8 and 9 formed. Overall, these results better address the nutritional features of protein fortifiers and fortified PDHM intended for nutrition of preterm infants.
Preterm infant; Milk protein hydrolyzates; Heat damage; Casomorphins; Digestion
Settore AGR/15 - Scienze e Tecnologie Alimentari
1-giu-2020
Article (author)
File in questo prodotto:
File Dimensione Formato  
FOODCHEM-S-19-06677.pdf

accesso aperto

Tipologia: Pre-print (manoscritto inviato all'editore)
Dimensione 1.77 MB
Formato Adobe PDF
1.77 MB Adobe PDF Visualizza/Apri
FC 2020.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 348.24 kB
Formato Adobe PDF
348.24 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/704623
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 9
  • ???jsp.display-item.citation.isi??? 7
social impact