Vitamin K is a cofactor for the function of the enzyme γ-glutamyl carboxylase, necessary for the activation of multiple vitamin K dependent-proteins. Vitamin K dependent-proteins (VKDPs) have important roles in bone health, vascular health, metabolism, reproduction as well as in cancer progression. Vitamin K deficiency is common in different conditions, including kidney disease, and it may influence the activity of VKDPs. This review discusses vitamin K status in human health and the physiologic and pathologic roles of VKDPs, beyond the established effects in skeletal and cardiovascular health.

Vitamin K effects in human health: new insights beyond bone and cardiovascular health / M. Fusaro, M. Gallieni, C. Porta, T.L. Nickolas, P. Khairallah. - In: JN. JOURNAL OF NEPHROLOGY. - ISSN 1121-8428. - 33:2(2020 Apr), pp. 239-249. [10.1007/s40620-019-00685-0]

Vitamin K effects in human health: new insights beyond bone and cardiovascular health

M. Gallieni
Secondo
;
2020

Abstract

Vitamin K is a cofactor for the function of the enzyme γ-glutamyl carboxylase, necessary for the activation of multiple vitamin K dependent-proteins. Vitamin K dependent-proteins (VKDPs) have important roles in bone health, vascular health, metabolism, reproduction as well as in cancer progression. Vitamin K deficiency is common in different conditions, including kidney disease, and it may influence the activity of VKDPs. This review discusses vitamin K status in human health and the physiologic and pathologic roles of VKDPs, beyond the established effects in skeletal and cardiovascular health.
Bone disease; Cancer; Chronic kidney disease; Vascular calcifications; Vitamin K
Settore MED/14 - Nefrologia
Settore MED/09 - Medicina Interna
apr-2020
19-dic-2019
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/703281
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