Previous studies have suggested that physical exercise may have an effect on the turnover of the endothelial compartment. Following a maximal exercise testing (Bruce protocol), a prompt and significant increase in the number of circulating endothelial cells (CECs) was detected (Δ 1 50% vs. basal; P = 0.0001) in 12 healthy volunteers, without significant changes in the marker of myocardial ischemia; the frequency of CECs correlated significantly with systolic blood pressure (SBP) and rate-pressure product at peak exercise (r = 0.78, P = 0.003, and r = 0.64, P = 0.03, respectively). These results support the role of peak SBP during maximal exercise possibly as mechanical factor facilitating the detachment of CECs and the endothelial turnover.

Systolic blood pressure peak during maximal exercise testing : a possible determinant of endothelial turnover in healthy subjects / M.M. Ciulla, C. Gianni, P. Broglia, S. Lonati, I. Silvestris, R. Paliotti, F. Giofrè, E. Rampoldi, A. Cortelezzi, F. Magrini. - In: AMERICAN JOURNAL OF HEMATOLOGY. - ISSN 0361-8609. - 84:7(2009 Jul), pp. 449-450. [10.1002/ajh.21424]

Systolic blood pressure peak during maximal exercise testing : a possible determinant of endothelial turnover in healthy subjects

M.M. Ciulla
Primo
;
C. Gianni
Secondo
;
S. Lonati;I. Silvestris;R. Paliotti;F. Giofrè;A. Cortelezzi
Penultimo
;
F. Magrini
Ultimo
2009

Abstract

Previous studies have suggested that physical exercise may have an effect on the turnover of the endothelial compartment. Following a maximal exercise testing (Bruce protocol), a prompt and significant increase in the number of circulating endothelial cells (CECs) was detected (Δ 1 50% vs. basal; P = 0.0001) in 12 healthy volunteers, without significant changes in the marker of myocardial ischemia; the frequency of CECs correlated significantly with systolic blood pressure (SBP) and rate-pressure product at peak exercise (r = 0.78, P = 0.003, and r = 0.64, P = 0.03, respectively). These results support the role of peak SBP during maximal exercise possibly as mechanical factor facilitating the detachment of CECs and the endothelial turnover.
Settore MED/15 - Malattie del Sangue
Settore MED/09 - Medicina Interna
Settore MED/11 - Malattie dell'Apparato Cardiovascolare
lug-2009
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/69191
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