Voluntary movements induce postural perturbations which are counteracted by Anticipatory Postural Adjustments (APAs). APAs build up long fixation chains toward available support points (inter-limb APAs), so as to grant whole body equilibrium, but also create short chains within the same limb where a distal segment is moved (intra-limb APAs), to stabilize the proximal segments. In order to elucidate the CNS structures governing intra-limb APAs, we compared healthy subjects and parkinsonian patients, assuming the latter as a model of basal ganglia dysfunction. Intra-limb APAs stabilizing the arm when the index-finger is briskly flexed were recorded in 13 parkinsonian patients and 10 age-matched healthy subjects. Index-finger movement was smaller in parkinsonian vs. healthy participants (p=0.01) and more delayed with respect to the onset of prime mover Flexor Digitorum Superficialis (FDS, p<0.0001). In agreement with the literature, in all healthy subjects the FDS activation was preceded by an inhibitory APA in Biceps Brachii (BB) and Anterior Deltoid (AD), and almost simultaneous to an excitatory APA in Triceps Brachii (TB). In parkinsonian patients no significant differences were found for TB and AD APA timings. However, only 4 patients developed an inhibitory APA in BB, as in healthy subjects; 5 actually developed a BB excitation and in 4 the BB APAs was lacking. The frequency of occurrence of normal sign, inverted sign and lacking BB APAs was different in healthy vs. parkinsonian participants (p=0.0016). This result suggests that also basal ganglia take part to the circuitry by shaping the pattern of intra-limb APAs.

The pattern of intra-limb APAs stabilising the arm during index-finger flexion is disrupted in parkinsonian patients / P. Cavallari, F. Bolzoni, R. Esposti, S. Marchese, N. Pozzi, U. Ramirez-Pasos, I. Isaias. ((Intervento presentato al 12. convegno Progress in Motor Control tenutosi a Amsterdam nel 2019.

The pattern of intra-limb APAs stabilising the arm during index-finger flexion is disrupted in parkinsonian patients

P. Cavallari
Primo
;
F. Bolzoni
Secondo
;
R. Esposti;S. Marchese;
2019

Abstract

Voluntary movements induce postural perturbations which are counteracted by Anticipatory Postural Adjustments (APAs). APAs build up long fixation chains toward available support points (inter-limb APAs), so as to grant whole body equilibrium, but also create short chains within the same limb where a distal segment is moved (intra-limb APAs), to stabilize the proximal segments. In order to elucidate the CNS structures governing intra-limb APAs, we compared healthy subjects and parkinsonian patients, assuming the latter as a model of basal ganglia dysfunction. Intra-limb APAs stabilizing the arm when the index-finger is briskly flexed were recorded in 13 parkinsonian patients and 10 age-matched healthy subjects. Index-finger movement was smaller in parkinsonian vs. healthy participants (p=0.01) and more delayed with respect to the onset of prime mover Flexor Digitorum Superficialis (FDS, p<0.0001). In agreement with the literature, in all healthy subjects the FDS activation was preceded by an inhibitory APA in Biceps Brachii (BB) and Anterior Deltoid (AD), and almost simultaneous to an excitatory APA in Triceps Brachii (TB). In parkinsonian patients no significant differences were found for TB and AD APA timings. However, only 4 patients developed an inhibitory APA in BB, as in healthy subjects; 5 actually developed a BB excitation and in 4 the BB APAs was lacking. The frequency of occurrence of normal sign, inverted sign and lacking BB APAs was different in healthy vs. parkinsonian participants (p=0.0016). This result suggests that also basal ganglia take part to the circuitry by shaping the pattern of intra-limb APAs.
8-lug-2019
Settore BIO/09 - Fisiologia
International Society of Motor Control
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The pattern of intra-limb APAs stabilising the arm during index-finger flexion is disrupted in parkinsonian patients / P. Cavallari, F. Bolzoni, R. Esposti, S. Marchese, N. Pozzi, U. Ramirez-Pasos, I. Isaias. ((Intervento presentato al 12. convegno Progress in Motor Control tenutosi a Amsterdam nel 2019.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/657014
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