Background: The plant kingdom represents an unlimited source of phytotherapeutics with promising perspectives in the field of anticancer drug discovery. Purpose: In this view, epithelial-mesenchymal transition (EMT) represents a novel and major target in anticancer therapy. Therefore, this narrative review aims to provide an updated overview on the bioactive phytochemicals with anti-EMT activity. Conclusion: Among the plant products reviewed, phenylpropanoids were the most investigated at preclinical phase, thus exhibiting a promising potential as anticancer drugs, though an evidence-based clinical efficacy is still lacking.

Epithelial-mesenchymal transition as a target for botanicals in cancer metastasis / B. Salehi, E.M. Varoni, M. Sharifi-Rad, S. Rajabi, P. Zucca, M. Iriti, J. Sharifi-Rad. - In: PHYTOMEDICINE. - ISSN 0944-7113. - 55(2019 Mar 01), pp. 125-136.

Epithelial-mesenchymal transition as a target for botanicals in cancer metastasis

E.M. Varoni;M. Iriti;
2019

Abstract

Background: The plant kingdom represents an unlimited source of phytotherapeutics with promising perspectives in the field of anticancer drug discovery. Purpose: In this view, epithelial-mesenchymal transition (EMT) represents a novel and major target in anticancer therapy. Therefore, this narrative review aims to provide an updated overview on the bioactive phytochemicals with anti-EMT activity. Conclusion: Among the plant products reviewed, phenylpropanoids were the most investigated at preclinical phase, thus exhibiting a promising potential as anticancer drugs, though an evidence-based clinical efficacy is still lacking.
Alkaloids; Anticancer phytotherapeutics; Bioactive phytochemicals; Chemoprevention; Isoprenoids; Phenylpropanoids; Molecular Medicine; Pharmacology; 3003; Drug Discovery; 3003; Pharmaceutical Science; Complementary and Alternative Medicine; 2708; Dermatology
Settore MED/28 - Malattie Odontostomatologiche
Settore AGR/12 - Patologia Vegetale
1-mar-2019
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/619722
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