The design of chiral synthetic polymers capable of self-assembling in solutions is receiving increasing attention for its biological implications. In this field, polyamidoamino acids (PAACs) are an emerging class of stimuli-responsive bioinspired synthetic polymers obtained by the stepwise polyaddition in pH > 9 aqueous solution of α-amino acids with N,N’-methylenebisacrylamide. The first example of this family, ARGO7, obtained from L- and D-arginine polyaddition, proved capable of self-assembly in aqueous solution into rigid pH dependent conformations. For all ARGO7 isomers, self-diffusion coefficients probed by pulsed-gradient spin-echo nuclear magnetic resonance (PGSE-NMR) reported values between 3 x 10-10 and 9 x 10-11 m2/s and Rh of 0.9 - 2 nm, consistent with compact random coils. It remains to be ascertained if selective chirality driven interactions may arise by mixing the D- or L- form of PAACs with soft chiral surfaces. As an example of the latter, sodium deoxycholate was chosen for its ability to form chiral micelle in aqueous solution, capable of interacting with protein and fatty acids in biological system.

PGSE NMR studies on complex formulation of aminoacid deriving polymers and sodium deoxycholate micelle / F. Lazzari, A.G. Manfredi, J. Alongi, P. Griffiths, E. Ranucci, P. Ferruti - In: Merck & Elsevier Young Chemists Symposium / [a cura di] F. Bella, L. Botta, R. Cucciniello, A. D’Urso, P. Franco, E. Lenci, G. Mazzone, M. Schlich, A. Soldà, R. Spezzano, S. Staderini, and L. Triggiani. - Ebook. - Roma : Società Chimica Italiana, 2018 Nov 19. - ISBN 9788894952032. - pp. 19-19 (( Intervento presentato al 18. convegno the Merck & Elsevier Young Chemists Symposium tenutosi a Rimini nel 2018.

PGSE NMR studies on complex formulation of aminoacid deriving polymers and sodium deoxycholate micelle

F. Lazzari
Primo
Writing – Original Draft Preparation
;
A.G. Manfredi
Secondo
;
J. Alongi;E. Ranucci
Penultimo
;
P. Ferruti
Ultimo
2018

Abstract

The design of chiral synthetic polymers capable of self-assembling in solutions is receiving increasing attention for its biological implications. In this field, polyamidoamino acids (PAACs) are an emerging class of stimuli-responsive bioinspired synthetic polymers obtained by the stepwise polyaddition in pH > 9 aqueous solution of α-amino acids with N,N’-methylenebisacrylamide. The first example of this family, ARGO7, obtained from L- and D-arginine polyaddition, proved capable of self-assembly in aqueous solution into rigid pH dependent conformations. For all ARGO7 isomers, self-diffusion coefficients probed by pulsed-gradient spin-echo nuclear magnetic resonance (PGSE-NMR) reported values between 3 x 10-10 and 9 x 10-11 m2/s and Rh of 0.9 - 2 nm, consistent with compact random coils. It remains to be ascertained if selective chirality driven interactions may arise by mixing the D- or L- form of PAACs with soft chiral surfaces. As an example of the latter, sodium deoxycholate was chosen for its ability to form chiral micelle in aqueous solution, capable of interacting with protein and fatty acids in biological system.
biobased surfactant; chirality; aminoacid deriving polymers
Settore CHIM/04 - Chimica Industriale
19-nov-2018
società chimica italiana giovani
Merck
Elsevier
https://www.soc.chim.it/sites/default/files/users/gru_giovani/documenti/Book of Abstracts 2018.pdf
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/604561
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