Cortexolone-17α-propionate (CP) is a topically active antiandrogen useful in the treatment of skin disorders. In the solid state, three anhydrous forms of this drug (CPI, CPII and CPIII) occur, together with one hydrated crystal (CPW). The single crystal structure of the monohydrated phase, CPW, compared with that of the anhydrous form CPIII, shows a markedly different solid state behavior. These latter pseudopolymorphic forms have also been fully characterized by spectroscopic methods.

Full spectroscopic characterization of two crystal pseudopolymorphic forms of the antiandrogen cortexolone 17α-propionate for topic application / P. Ferraboschi, M. Sala, R. Stradi, L. Ragonesi, C. Gagliardi, P. Lanzarotti, E.M. Ragg, M. Mori, F. Meneghetti. - In: STEROIDS. - ISSN 0039-128X. - 128(2017), pp. 95-104. [10.1016/j.steroids.2017.09.003]

Full spectroscopic characterization of two crystal pseudopolymorphic forms of the antiandrogen cortexolone 17α-propionate for topic application

P. Ferraboschi;R. Stradi;L. Ragonesi;E..M. Ragg;M. Mori;F. Meneghetti
2017

Abstract

Cortexolone-17α-propionate (CP) is a topically active antiandrogen useful in the treatment of skin disorders. In the solid state, three anhydrous forms of this drug (CPI, CPII and CPIII) occur, together with one hydrated crystal (CPW). The single crystal structure of the monohydrated phase, CPW, compared with that of the anhydrous form CPIII, shows a markedly different solid state behavior. These latter pseudopolymorphic forms have also been fully characterized by spectroscopic methods.
Solid-state NMR spectroscopy; Solvopolymorphism; Steroidal hormone; X-ray diffractometry; Biochemistry; Molecular Biology; Pharmacology; Endocrinology; Clinical Biochemistry; Organic Chemistry
Settore CHIM/08 - Chimica Farmaceutica
Settore CHIM/06 - Chimica Organica
2017
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/526232
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