In coronary artery disease (CAD) epicardial adipose tissue (EAT) shows an elevated inflammatory infiltrate. Toll-like receptors (TLRs) are important mediators of adipose tissue inflammation and they are able to recognize endogenous products released by damaged cells. Because adipocyte death may be driven by hypertrophy, our aim was to investigate in CAD and non-CAD patients the association between EAT adipocyte size, macrophage infiltration/polarization and TLR-2 and TLR-4 expression.
Epicardial adipocyte hypertrophy : association with M1-polarization and toll-like receptor pathways in coronary artery disease patients / E. Vianello, E. Dozio, F. Arnaboldi, M.G. Marazzi, C. Martinelli, J. Lamont, L. Tacchini, A. Sigrüner, G. Schmitz, M.M. Corsi Romanelli. - In: NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES. - ISSN 0939-4753. - 26:3(2016 Mar), pp. 246-253. [10.1016/j.numecd.2015.12.005]
Epicardial adipocyte hypertrophy : association with M1-polarization and toll-like receptor pathways in coronary artery disease patients
E. Vianello;E. Dozio;F. Arnaboldi;M.G. Marazzi;C. Martinelli;L. Tacchini;M.M. Corsi Romanelli
2016
Abstract
In coronary artery disease (CAD) epicardial adipose tissue (EAT) shows an elevated inflammatory infiltrate. Toll-like receptors (TLRs) are important mediators of adipose tissue inflammation and they are able to recognize endogenous products released by damaged cells. Because adipocyte death may be driven by hypertrophy, our aim was to investigate in CAD and non-CAD patients the association between EAT adipocyte size, macrophage infiltration/polarization and TLR-2 and TLR-4 expression.
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