The chemokine system includes at least three "silent" receptors, DARC, D6 and CCX CKR, with distinct specificity and tissue distribution. D6 binds most inflammatory, but not homeostatic, CC chemokines and shuttles in a ligand-independent way from the plasma membrane to endocytic compartments where chemokines are targeted to degradation. In vitro and in vivo evidence, including results with gene-targeted mice, is consistent with the view that D6 acts as a decoy and scavenger for inflammatory CC chemokines. Thus, D6 has unique functional and structural features, which make it ideally adapted to act as a chemokine decoy and scavenger receptor, strategically located on lymphatic endothelium to dampen inflammation in tissues and draining lymph nodes.

Silent chemoattractant receptors : D6 as a decoy and scavenger receptor for inflammatory CC chemokines / M. Locati, Y. Martinez de la Torre, E.R. Galliera, R. Bonecchi, H. Bodduluri, G. Vago, A. Vecchi, A. Mantovani. - In: CYTOKINE & GROWTH FACTOR REVIEWS. - ISSN 1359-6101. - 16:6(2005), pp. 679-686. [10.1016/j.cytogfr.2005.05.003]

Silent chemoattractant receptors : D6 as a decoy and scavenger receptor for inflammatory CC chemokines

M. Locati
Primo
;
Y. Martinez de la Torre
Secondo
;
E.R. Galliera;R. Bonecchi;G. Vago;A. Mantovani
Ultimo
2005

Abstract

The chemokine system includes at least three "silent" receptors, DARC, D6 and CCX CKR, with distinct specificity and tissue distribution. D6 binds most inflammatory, but not homeostatic, CC chemokines and shuttles in a ligand-independent way from the plasma membrane to endocytic compartments where chemokines are targeted to degradation. In vitro and in vivo evidence, including results with gene-targeted mice, is consistent with the view that D6 acts as a decoy and scavenger for inflammatory CC chemokines. Thus, D6 has unique functional and structural features, which make it ideally adapted to act as a chemokine decoy and scavenger receptor, strategically located on lymphatic endothelium to dampen inflammation in tissues and draining lymph nodes.
Chemokine receptors; Chemokines; D6; Decoy receptors; Inflammation
Settore MED/08 - Anatomia Patologica
Settore MED/04 - Patologia Generale
2005
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/8768
Citazioni
  • ???jsp.display-item.citation.pmc??? 27
  • Scopus 100
  • ???jsp.display-item.citation.isi??? 93
social impact