Poly(amidoamine)s are biocompatible biodegradable polymers, which can be easily functionalized with a no. of bioactive and biomimetic compds. Co-polymn. of these polymers with 4-aminobutyl guanidine (agmatine) leads to an RGD mimicking structure. Hydrogels based on this structure showed an enhanced cell adhesion and could be chem. linked to a glass substrate to create a bioadhesive support for cell growth. Preliminary optimization and cell adhesion tests on Madin-Darby Canine Kidney cells were performed, both on functionalized and non-functionalized structures, with promising results
Novel poly(amidoamine)-based hydrogels as scaffolds for tissue engineering. / E. Emilitri, F. Guizzardi, C. Lenardi, M. Suardi, E. Ranucci, P. Ferruti.. - In: MACROMOLECULAR SYMPOSIA. - ISSN 1022-1360. - 266:1(2008), pp. 41-47.
Novel poly(amidoamine)-based hydrogels as scaffolds for tissue engineering.
C. Lenardi;E. RanucciPenultimo
;P. Ferruti.Ultimo
2008
Abstract
Poly(amidoamine)s are biocompatible biodegradable polymers, which can be easily functionalized with a no. of bioactive and biomimetic compds. Co-polymn. of these polymers with 4-aminobutyl guanidine (agmatine) leads to an RGD mimicking structure. Hydrogels based on this structure showed an enhanced cell adhesion and could be chem. linked to a glass substrate to create a bioadhesive support for cell growth. Preliminary optimization and cell adhesion tests on Madin-Darby Canine Kidney cells were performed, both on functionalized and non-functionalized structures, with promising resultsPubblicazioni consigliate
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