An efficient and convenient route for the preparation of natural and unnatural hystidine by asymmetric hydrogenation with Rhodium-phosphine complexes is described. The reductions were performed in presence of HBF4 to generate essential imidazolyl cation. Stereoselective incorporation of D2 into the α,β-positions was obtained by catalytic deuteration in presence of MeOD.
Histidine and deuterium labelled histidine by asymmetric catalytic reduction with gaseous H-2 or D-2 : the role of strong non-coordinating acids / E. Cesarotti, I. Rimoldi, D. Zerla, G. Aldini. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 19:3(2008), pp. 273-278. [10.1016/j.tetasy.2007.12.013]
Histidine and deuterium labelled histidine by asymmetric catalytic reduction with gaseous H-2 or D-2 : the role of strong non-coordinating acids
E. CesarottiPrimo
;I. RimoldiSecondo
;D. ZerlaPenultimo
;G. AldiniUltimo
2008
Abstract
An efficient and convenient route for the preparation of natural and unnatural hystidine by asymmetric hydrogenation with Rhodium-phosphine complexes is described. The reductions were performed in presence of HBF4 to generate essential imidazolyl cation. Stereoselective incorporation of D2 into the α,β-positions was obtained by catalytic deuteration in presence of MeOD.Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.