Repeated exposure to HIV does not necessarily result in infection and HIV infection does not inevitably lead to the development of the AIDS. Multiple immunological and genetic features can confer resistance to HIV acquisition and progression at different steps in viral infection; a full understanding of these mechanisms could result in the development of novel therapeutic and vaccine approaches for HIV infection. In this review, we focus on the genetic mechanisms associated with resistance to HIV infection and to the progression to AIDS.
Genetic correlates of protection against HIV infection : the ally within / L. Piacentini, M. Biasin, C. Fenizia, M. Clerici. - In: JOURNAL OF INTERNAL MEDICINE. - ISSN 0954-6820. - 265:1(2009 Jan), pp. 110-124. [10.1111/j.1365-2796.2008.02041.x]
Genetic correlates of protection against HIV infection : the ally within
L. PiacentiniPrimo
;M. BiasinSecondo
;C. FeniziaPenultimo
;M. ClericiUltimo
2009
Abstract
Repeated exposure to HIV does not necessarily result in infection and HIV infection does not inevitably lead to the development of the AIDS. Multiple immunological and genetic features can confer resistance to HIV acquisition and progression at different steps in viral infection; a full understanding of these mechanisms could result in the development of novel therapeutic and vaccine approaches for HIV infection. In this review, we focus on the genetic mechanisms associated with resistance to HIV infection and to the progression to AIDS.Pubblicazioni consigliate
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