We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in approximately 25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11)
New susceptibility locus for coronary artery disease on chromosome 3q22.3 / J. Erdmann, A. Grosshennig, P.S. Braund, I.R. Konig, C. Hengstenberg, A.S. Hall, P. Linsel-Nitschke, S. Kathiresan, B. Wright, D.A. Tregouet, F. Cambien, P. Bruse, Z. Aherrahrou, A.K. Wagner, K. Stark, S.M. Schwartz, V. Salomaa, R. Elosua, O. Melander, B.F. Voight, C.J. O'Donnell, L. Peltonen, D.S. Siscovick, D. Altshuler, P.A. Merlini, F. Peyvandi, L. Berardinelli, D. Ardissino, A. Schillert, S. Blankenberg, T. Zeller, P. Wild, D.F. Schwarz, L. Tiret, C. Perret, S. Schreiber, N.E. El Mokhtari, A. Schaefer, W. Maerz, W. Renner, P. Bugert, H. Klueter, J. Schrezenmeir, D. Rubin, S.G. Ball, A.J. Balmforth, H.E. Wichmann, T. Meitinger, M. Fischer, C. Meisinger, J. Baumert, A. Peters, W.H. Ouwehand, Italian Atherosclerosis Thrombosis and Vascular Biology Working Group, Myocardial Infarction Genetics Consortium, Wellcome Trust Case Control Consortium, Cardiogenics Consortium, P. Deloukas, J.R. Thompson, A. Ziegler, N.J. Samani, H. Schunkert. - In: NATURE GENETICS. - ISSN 1061-4036. - 41:3(2009 Mar), pp. 280-282.
New susceptibility locus for coronary artery disease on chromosome 3q22.3
F. Peyvandi;
2009
Abstract
We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in approximately 25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11)
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