In this study memory for public events was evaluated in 15 amnesic mild cognitive impairment (aMCI) patients, whose clinical diagnosis was refined through a stringent selection procedure. A total of 9 patients were longitudinally reassessed over an 18-month period. About half of the participants were impaired at baseline and nearly 80% at the end of the 18-month follow-up. Moreover, retrograde memory declined significantly over time. Evidence of a pathological Ribot-type temporal gradient was found in about half of the aMCI patients. This is the first report of a remote memory deficit in aMCI. It highlights amnesia for public events as a frequent accompaniment of this condition. The findings tie in with the hypothesized role of the hippocampal complex in long-term memory.
Mild Cognitive Impairment does entail retrograde amnesia for pubblic events / I. Bizzozero, F. Lucchelli, M.C. Saetti, H. Spinnler. - In: NEUROPSYCHOLOGY, DEVELOPMENT, AND COGNITION. SECTION A, JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY. - ISSN 1380-3395. - 31:1(2009 Jan), pp. 48-56.
Mild Cognitive Impairment does entail retrograde amnesia for pubblic events
M.C. SaettiPenultimo
;H. SpinnlerUltimo
2009
Abstract
In this study memory for public events was evaluated in 15 amnesic mild cognitive impairment (aMCI) patients, whose clinical diagnosis was refined through a stringent selection procedure. A total of 9 patients were longitudinally reassessed over an 18-month period. About half of the participants were impaired at baseline and nearly 80% at the end of the 18-month follow-up. Moreover, retrograde memory declined significantly over time. Evidence of a pathological Ribot-type temporal gradient was found in about half of the aMCI patients. This is the first report of a remote memory deficit in aMCI. It highlights amnesia for public events as a frequent accompaniment of this condition. The findings tie in with the hypothesized role of the hippocampal complex in long-term memory.Pubblicazioni consigliate
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